513068-96-7

Basic information

• Product Name: 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one
• Synonyms: 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one
• CAS NO: 513068-96-7
• Molecular Weight: 296.298
• Mol File: 513068-96-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 112-114 °C
• Boiling Point: 494.2±45.0 °C(Predicted)
• Density: 1.361±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one(513068-96-7)
• EPA Substance Registry System: 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one(513068-96-7)

Safety Data

• Hazardous Substances Data: 513068-96-7(Hazardous Substances Data)

Upstream product

• 7517-99-9 5-hydroxymethyl-2-oxazolidinone 
• 513068-89-8 4-(4-bromo-2-fluorophenyl)morpholine 
• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 513068-92-3 3-{3-fluoro-4-morpholinophenyl}-5-(tetrahydro-2H-2-pyranyloxy-methyl)-2-oxazolidinone 
• 1385053-40-6 C₁₈H₂₅FN₂O₄ 

Downstream Products

• 912359-80-9 (S)-[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]aminomethane 
• 168828-90-8 (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine 
• 224323-50-6 linezolid 
• 165800-03-3 linezolid 
• 224323-50-6 linezolid 
• 858344-36-2 methanesulfonic acid 3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-oxazolidin-5-ylmethyl ester 

Relevant articles and documents

A new method for the oxazolidinone key intermediate of linezolid and its formal synthesis

-

Highly efficient CuI-catalyzed coupling of aryl bromides with oxazolidinones using Buchwald's protocol: a short route to linezolid and toloxatone.

[reaction: see text] Coupling of a variety of substituted aryl bromides with oxazolidinones has been achieved using the Buchwald protocol for the amidation of aryl halides. This procedure is exemplified by the synthesis of two medicinally important molecules, linezolid and toloxatone.