858344-36-2

Basic information

• Product Name: 3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone
• Synonyms: 3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone;(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate
• CAS NO: 858344-36-2
• Molecular Formula: C₁₅H₁₉FN₂O₆S
• Molecular Weight: 374.387
• EINECS: 1312995-182-4
• Mol File: 858344-36-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.418
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone(858344-36-2)
• EPA Substance Registry System: 3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone(858344-36-2)

Safety Data

• Hazardous Substances Data: 858344-36-2(Hazardous Substances Data)

Usage

General Description

3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone is a chemical compound with potential medicinal properties. It contains a fluoro-phenyl group along with a morpholinyl group and a sulfonyl oxy methyl group, making it a complex structure. The oxazolidinone ring in the compound suggests that it may have antibiotic or antimicrobial properties. Additionally, the presence of the sulfonyl group indicates potential medicinal applications, as sulfonyl compounds are widely used in pharmaceuticals. Overall, this compound has the potential to be investigated for its pharmaceutical properties and could be of interest in drug discovery and development.

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 513068-96-7 3-(3-fluoro-4-morpholin-4-yl-phenyl)-5-hydroxymethyl-oxazolidin-2-one 
• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 513068-89-8 4-(4-bromo-2-fluorophenyl)morpholine 
• 513068-92-3 3-{3-fluoro-4-morpholinophenyl}-5-(tetrahydro-2H-2-pyranyloxy-methyl)-2-oxazolidinone 
• 952680-48-7 (3-fluoro-4-morpholin-4-yl-phenyl)carbamic acid tert-butyl ester 
• 1385053-40-6 C₁₈H₂₅FN₂O₄ 

Downstream Products

• 224323-50-6 linezolid 
• 1213258-42-4 3-(3-fluoro-4-morpholinophenyl)-5-((3-oxoisothiazol-2(3H)-yl)methyl)oxazolidin-2-one 
• 912359-80-9 (S)-[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]aminomethane 
• 168828-90-8 (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine 
• 224323-50-6 linezolid 
• 165800-03-3 linezolid 

Relevant articles and documents

A new method for the oxazolidinone key intermediate of linezolid and its formal synthesis

-

Highly efficient CuI-catalyzed coupling of aryl bromides with oxazolidinones using Buchwald's protocol: a short route to linezolid and toloxatone.

[reaction: see text] Coupling of a variety of substituted aryl bromides with oxazolidinones has been achieved using the Buchwald protocol for the amidation of aryl halides. This procedure is exemplified by the synthesis of two medicinally important molecules, linezolid and toloxatone.