51420-71-4

Basic information

• Product Name: 5,7-dimethyl-1,8-naphthyridin-2(1H)-one
• Synonyms: 5,7-dimethyl-1,8-naphthyridin-2(1H)-one;5,7-Dimethyl-1,8-naphthyridine-2-ol;1,8-Naphthyridin-2(1H)-one, 5,7-dimethyl-;5,7-Dimethyl-[1,8]naphthyridin-2-ol;5,7-dimethyl-1,8-naphthyridin-2-ol;5,7-dimethyl-1H-1,8-naphthyridin-2-one;MFCD00066907
• CAS NO: 51420-71-4
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• EINECS: 257-195-2
• Mol File: 51420-71-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 377.4°C at 760 mmHg
• Flash Point: 182.1°C
• Appearance: /
• Density: 1.178g/cm³
• Vapor Pressure: 6.76E-06mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5,7-dimethyl-1,8-naphthyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dimethyl-1,8-naphthyridin-2(1H)-one(51420-71-4)
• EPA Substance Registry System: 5,7-dimethyl-1,8-naphthyridin-2(1H)-one(51420-71-4)

Safety Data

• Hazardous Substances Data: 51420-71-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O/c1-6-5-7(2)11-10-8(6)3-4-9(13)12-10/h3-5H,1-2H3,(H,11,12,13)

Upstream product

• 39565-07-6 7-amino-2,4-dimethyl-1,8-naphthyridine 
• 141-86-6 2.6-diaminopyridine 
• 123-54-6 acetylacetone 

Downstream Products

• 77223-21-3 7-chloro-2,4-dimethyl-1,8-naphthyridine 
• 79060-65-4 4-<(2-oxo-2-phenyl)ethyl>-7-hydroxy-2-methyl-1,8-naphthyridine 
• 79060-68-7 2-<(2-oxo-2-phenyl)ethyl>-7-hydroxy-4-methyl-1,8-naphthyridine 
• 7544-64-1 2,4-dimethyl[1,8]naphthyridine 
• 65541-95-9 5,7-dimethyl-1,2,3,4-tetrahydro[1,8]naphthyridine 

Relevant articles and documents

2-Amino-5,7-dimethyl-1,8-naphthyridine as a fluorescent reagent for the determination of nitrite

A new fluorescent reagent 2-amino-5,7-dimethyl-1,8-naphthyridine (ADMND) was proposed for the determination of trace nitrite. The reaction is based on the diazotization of naphthyridine amine with nitrite to form a diazonium salt that hydrolyzed when boiling to give hydroxyl group substituted naphthyridine. Fluorescence quenching degree of ADMND by nitrite ion is linear in the nitrite concentration range of 1 × 10-7 to 2.5 × 10-6 mol l-1 with a detection limit of 4.06 × 10-8 mol l-1. Reaction and determination acidity for nitrite is the same which made the method much simpler compared with the widely accepted fluorescence method with DAN as a fluorescence reagent.

The First 1-Hydroxypropylidenebisphosphonic Acid with 1,8-Naphthyridinone Substituent: Synthesis and Structure

1-Hydroxy-3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propylidenebisphosphonic acid has been synthesized. The structure of the acid and its precursors synthesized for the first time, 3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propionic acid and the corresponding methyl ester, in the solid state and in the DMSO solution has been elucidated by means of vibrational (IR and Raman) and multinuclear (1H, 13C, and 31P) NMR spectroscopy.

Pyridine and related aza heterocycle derivatives as cardiovascular agents

Novel pharmaceutical compounds and compositions having nitrogen containing ring systems which may be represented by the following structural formula: wherein R1 or R3 is a moiety of the formula: wherein R6 is selected from either hydrogen or acetyl; R7 is selected from 2, 3 or 4-pyridyl or 1-imidazolyl and Q is -(CH2)n, where n is an integer from 1 to 5 and R1 and R2, R2 and R3, R3 and R4 or R4 and R5 taken together may be -CH=CH-CH=CH-. The compounds and compositions are useful as inhibitors of thromboxane synthetase and in the treatment of hypertension and arrythmia in mammals.