51484-40-3 Usage
Description
N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide is a monocarboxylic acid amide that is formed through the formal condensation of the carboxy group from biphenyl-4-ylacetic acid with the amino group of 2-aminopyridine. N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide has been identified for its potential therapeutic applications, particularly in the treatment of rheumatoid arthritis.
Uses
Used in Pharmaceutical Industry:
N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide is used as a therapeutic agent for the treatment of rheumatoid arthritis. Its application is based on its ability to modulate the immune system and reduce inflammation, which are key factors in the pathology of rheumatoid arthritis.
Originator
Difenax,Zambeletti,Italy,1977
Manufacturing Process
23 g (0.1 mol) diphenylacetic acid chloride dissolved in 300 cc anhydrous
ethyl ether are slowly added dropwise to a solution of 19 g (0.2 mol) 2-
aminopyridine in 300 cc anhydrous ethyl ether. The reaction mixture is
agitated and the temperature is kept at between 5°C and 10°C with an ice
bath. After the addition has been completed, the agitation of the mixture is
continued and the temperature is allowed to rise to 20°C to 25°C. After leaving to stand for a few hours, the gummy precipitate solidifies and
becomes filterable. After separating off the precipitate, the ether is evaporated
under reduced pressure to a volume of about 100 cc.The ether is left to stand at a low temperature below 10°C when the
remaining portion of the product precipitates and is filtered off and added to
the first precipitate. The product thus obtained is thoroughly washed, first in
water and then in a solution of sodium bicarbonate, and then again in water.
After drying in air, the product is crystallized from anhydrous ethanol or from
acetone and water. The analytical data correspond to calculated values. Yield
is 18 g; MP 122°C to 124°C.
Therapeutic Function
Antiinflammatory
Check Digit Verification of cas no
The CAS Registry Mumber 51484-40-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,4,8 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 51484-40:
(7*5)+(6*1)+(5*4)+(4*8)+(3*4)+(2*4)+(1*0)=113
113 % 10 = 3
So 51484-40-3 is a valid CAS Registry Number.
51484-40-3Relevant articles and documents
Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters
Ronson, Thomas O.,Renders, Evelien,Van Steijvoort, Ben F.,Wang, Xubin,Wybon, Clarence C. D.,Prokopcová, Hana,Meerpoel, Lieven,Maes, Bert U. W.
, p. 482 - 487 (2019/01/04)
A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 by-product can be recycled.
Physicochemical profile of a new antiinflammatory drug: Difenpiramide
Trebbi,Filippi
, p. 729 - 738 (2007/10/05)
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