52323-93-0

Basic information

• Product Name: Benzene, 1-(methylsulfonyl)-4-(methylthio)-
• CAS NO: 52323-93-0
• Molecular Formula: C8H10O2S2
• Molecular Weight: 202.298
• Mol File: 52323-93-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(methylsulfonyl)-4-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(methylsulfonyl)-4-(methylthio)-(52323-93-0)
• EPA Substance Registry System: Benzene, 1-(methylsulfonyl)-4-(methylthio)-(52323-93-0)

Safety Data

• Hazardous Substances Data: 52323-93-0(Hazardous Substances Data)

Upstream product

• 123-09-1 4-chlorophenyl methyl sulfide 
• 20277-69-4 sodium methansulfinate 
• 3466-32-8 4-bromoohenyl methyl sulfone 
• 867-44-7 S-Methylisothiourea sulfate 
• 3814-25-3 4-(methylsulfonyl)benzenethiol 
• 74-88-4 methyl iodide 
• 512-56-1 trimethyl phosphite 
• 35371-03-0 4-iodothioanisole 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 147895-43-0 S-methylisothiourea hemisulphate 
• 104-95-0 (4-bromophenyl)thioanisole 
• 5470-49-5 4-methanesulfonylphenylamine 
• 2976-30-9 1-methanesulfonyl-4-nitrobenzene 

Downstream Products

• 27839-92-5 2-(4-Methanesulfonyl-benzenesulfonyl)-1-phenyl-ethanone 
• 15979-81-4 4-(methylsulfonyl)-N-phenylaniline 
• 22821-76-7 4-(methylsulfonyl)benzonitrile 
• 22821-86-9 1,4-bis(methanesulfonyl)benzene 

Relevant articles and documents

Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers

We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis.

General sulfone construction: Via sulfur dioxide surrogate control

A highly efficient one-step synthesis of alkyl-alkyl and aryl-alkyl sulfones with a facile combination of halides, sulfur dioxide surrogates and phosphate esters is described. When thiourea dioxide was employed as a reductive sulfur dioxide surrogate, alkyl-alkyl sulfones were obtained under transition metal free conditions. Aryl-alkyl sulfones were obtained with an extremely low catalytic loading (0.2 mol%) via altering the mask of sulfur dioxide surrogates to sodium dithionite. A phosphate ester was employed as a stable and readily available alkyl source. Notably, this protocol has been applied to the late-stage modification of natural products and bioactive molecules.

Transition-Metal-Free Aryl-Heteroatom Bond Formation via C-S Bond Cleavage

Aryl-heteroatom bonds (C-Het) are almost ubiquitously present in chemical molecules. However, methods for diverse C-Het bond formations from a simple substrate are limited. Herein, we report a convenient and efficient C-S bond transformation of aryl sulfoniums to various C-Het bonds (C-O, C-S, C-Sn, C-Si, C-Se) in the absence of any transition-metal catalyst. These reactions proceeded in mild conditions with a wide substrate scope.