52898-51-8

Basic information

• Product Name: N-methoxy-N-methyl-4-nitrobenzamide
• Synonyms: N-methoxy-N-methyl-4-nitrobenzamide
• CAS NO: 52898-51-8
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.1867
• Mol File: 52898-51-8.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-methoxy-N-methyl-4-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methoxy-N-methyl-4-nitrobenzamide(52898-51-8)
• EPA Substance Registry System: N-methoxy-N-methyl-4-nitrobenzamide(52898-51-8)

Safety Data

• Hazardous Substances Data: 52898-51-8(Hazardous Substances Data)

Usage

General Description

N-methoxy-N-methyl-4-nitrobenzamide is a chemical compound with the molecular formula C9H10N2O4. It is a derivative of 4-nitrobenzamide, with a methoxy and a methyl group attached to the nitrogen atom. N-methoxy-N-methyl-4-nitrobenzamide is used in the synthesis of various pharmaceuticals and agrochemicals, and it has been studied for its potential biological activities, particularly in the fields of medicine and agriculture. N-methoxy-N-methyl-4-nitrobenzamide is known for its nitro group, which can affect its reactivity and properties, and it may have applications in drug development and crop protection. Overall, this compound has potential uses in various industries and research fields due to its unique molecular structure and properties.

Upstream product

• 1613-77-0 N-hydroxy-N-methyl-4-nitrobenzamide 
• 6214-19-3 methyl p-methoxybenzenesulfonate 
• 53913-62-5 C₈H₇N₂O₄^(1-) 
• 33613-52-4 dimethylphenyl sulfonium tetrafluoroborate 
• 29829-22-9 S-methyldibenzothiophenium tetrafluoroborate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 100-09-4 4-methoxybenzoic acid 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 586-78-7 para-nitrophenyl bromide 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 555-16-8 4-nitrobenzaldehdye 
• 765287-09-0 4,4-diethoxy-1-(4-nitrophenyl)but-2-yn-1-one 
• 619-72-7 4-nitrobenzonitrile 
• 1599529-11-9 (4-aminophenyl)(1-methyl-1H-imidazol-5-yl)methanone 
• 1599529-30-2 (2,4-dichloro-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone 
• 1599529-31-3 (4-chloro-2-methoxy-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone 
• 1599529-10-8 (1-methyl-1H-imidazol-5-yl)(4-nitrophenyl)methanone 
• 2585-23-1 N-methyl-4-nitrobenzamide 
• 16208-23-4 2,2‐dichloro‐1‐(4‐nitrophenyl)ethan‐1‐one 
• 89100-22-1 (4-nitrophenyl)(4-(-trifluoromethyl)phenyl)methanone 
• 51207-98-8 N-butyl-4-nitrobenzamide 

Relevant articles and documents

Annulation-retro-Claisen cascade of bifunctional peroxides for the synthesis of lactone natural products

A new and highly efficient annulation-retro-Claisen cascade, which involves the [4 + 1] or [5 + 1] annulation of α-benzoylacetates with bielectrophilic peroxides and a subsequent debenzoylation process under mild basic conditions, has been developed for the rapid construction of valuable tetrahydrofuran- and dihydropyran-2-carboxylates in good yields. By employing the new reaction, the unified total synthesis of γ- and δ-lactone natural products such as (±)-tanikolide, (±)-goniothalamins, (±)-7-epi-goniodiol, and (±)-plakolide A has been accomplished in 4-7 steps.

Systematic Evaluation of 1,2-Migratory Aptitude in Alkylidene Carbenes

Alkylidene carbenes undergo rapid inter- and intramolecular reactions and rearrangements, including 1,2-migrations of β-substituents to generate alkynes. Their propensity for substituent migration exerts profound influence over the broader utility of alkylidene carbene intermediates, yet prior efforts to categorize 1,2-migratory aptitude in these elusive species have been hampered by disparate modes of carbene generation, ultrashort carbene lifetimes, mechanistic ambiguities, and the need to individually prepare a series of 13C-labeled precursors. Herein we report on the rearrangement of 13C-alkylidene carbenes generated in situ by the homologation of carbonyl compounds with [13C]-Li-TMS-diazomethane, an approach that obviates the need for isotopically labeled substrates and has expedited a systematic investigation (13C{1H} NMR, DLPNO-CCSD(T)) of migratory aptitudes in an unprecedented range of more than 30 alkylidene carbenes. Hammett analyses of the reactions of 26 differentially substituted benzophenones reveal several counterintuitive features of 1,2-migration in alkylidene carbenes that may prove of utility in the study and synthetic application of unsaturated carbenes more generally.

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.