5336-50-5

Basic information

• Product Name: ethyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate
• Synonyms: ethyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate
• CAS NO: 5336-50-5
• Molecular Formula: C₁₄H₁₅NO₄
• Molecular Weight: 261.2732
• Mol File: 5336-50-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 133-134 °C
• Boiling Point: 394.5°Cat760mmHg
• Flash Point: 192.4°C
• Appearance: /
• Density: 1.273g/cm³
• Vapor Pressure: 1.97E-06mmHg at 25°C
• Refractive Index: 1.566
• PKA: 7.98±0.20(Predicted)
• CAS DataBase Reference: ethyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate(5336-50-5)
• EPA Substance Registry System: ethyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate(5336-50-5)

Safety Data

• Hazardous Substances Data: 5336-50-5(Hazardous Substances Data)

Usage

General Description

Ethyl 1-benzyl-4,5-dioxopyrrolidine-3-carboxylate is a chemical compound that belongs to the class of organic compounds known as dioxopyrrolidines. It is derived from the natural compound pyrrolidin-3-one, which is a five-membered lactam used in the synthesis of pharmaceuticals. This chemical has potential bioactivity and is often used as a building block in the synthesis of other compounds. It is commonly used in the pharmaceutical industry for the manufacturing of drugs with various therapeutic applications. Additionally, it has been studied for its potential use in treating certain medical conditions. Overall, this compound has important applications in drug development and medicinal chemistry.

InChI:InChI=1/C14H15NO4/c1-2-19-14(18)11-9-15(13(17)12(11)16)8-10-6-4-3-5-7-10/h3-7,11H,2,8-9H2,1H3

Upstream product

• 23583-21-3 ethyl-3-benzylamino propionate 
• 95-92-1 oxalic acid diethyl ester 
• 100-46-9 benzylamine 
• 140-88-5 ethyl acrylate 
• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 23574-01-8 3-benzylamino-propionic acid methyl ester 

Downstream Products

• 102460-78-6 4-(2-amino-phenylimino)-1-benzyl-5-oxo-pyrrolidine-3-carboxylic acid ethyl ester 
• 58486-00-3 1-benzylpyrrolidine-2,3-dione 
• 83794-09-6 1-benzyl-4-(4-methoxybenzylidene)-pyrrolidine-2,3-dione 
• 83794-07-4 2,6-Dibenzyl-8-(4-methoxy-phenyl)-1,2,6,7-tetrahydro-2,4,6-triaza-s-indacene-3,5-dione 
• 83793-99-1 2,6-Dibenzyl-8-(4-methoxy-phenyl)-1,2,4,6,7,8-hexahydro-2,4,6-triaza-s-indacene-3,5-dione 
• 142774-23-0 N-(3-methylisothiazol-5-yl)-1-benzyl-4,5-dioxopyrrolidine-3-carboxamide 
• 915296-85-4 (E)-1-benzyl-4-(2,4-dichlorobenzylidene)pyrrolidine-2,3-dione 
• 35921-27-8 1-benzyl-4-(2-chlorophenyl) pyrrolidine-2,3-dione 
• 4805-28-1 1-benzoyl-5-benzyl-2-(4-chlorophenyl)-5-azaspiro[2.4]heptane-6,7-dione 

Relevant articles and documents

Au(I)/(R)-BINOL-Ti(IV) concerted catalyzed asymmetric cascade cycloaddition reaction of arylalkynols

An efficient catalytic asymmetric cascade cycloaddition reaction of arylalkynols with dioxopyrrolidines was developed. This reaction was achieved using Au(I) and (R)-BINOL-Ti(IV) bimetallic catalysts and exclusively delivered a series of chiral oxo-bridged bicyclic benzooxacine compounds in up to 86% yield with 96% ee as well as >33:1 dr. Meanwhile, three new σ bonds and three new stereogenic centers were formed in a one-pot process.

KRAS G12C Mutant protein inhibitors

The invention discloses compounds which irreversibly inhibit KRAS G12C mutation. A pharmaceutically acceptable salt and of the compound contains the compound or a salt thereof, and the invention also discloses an application of the compound or a salt and of the compound in the treatment KRAS G12C of a proliferative disease such as a sudden tumor.

Oxindole spiro-tetrahydrofuran compound as well as preparation method and application thereof

The invention provides an indole tetrahydrofuran oxide compound or a crystal form thereof, wherein the indole tetrahydrofuran oxide compound is as shown in a formula (I). R1 is selected from benzene rings, naphthalene rings and thiophene rings or cinnamyl, R2 is selected from H, F, Cl, Br and I or C1-3 alkoxy, R3 is selected from H and benzyl or C1-C3 alkyl, and R4 is H, F, Cl, Br, I and C1-3 alkoxy or C1-C3 alkyl. The invention further provides a method for preparing the compound. The compound is simple and convenient in preparation method, moderate in reaction and high in yield and has anti-tumor activity and a wide market application prospect.