541546-97-8

Basic information

• Product Name: 1,4-dideoxy-1,4-epithio-2,3,5-tris-O-[(4-methoxyphenyl)methyl]-D-Ribitol
• Synonyms: 1,4-dideoxy-1,4-epithio-2,3,5-tris-O-[(4-methoxyphenyl)methyl]-D-Ribitol
• CAS NO: 541546-97-8
• Molecular Weight: 0
• Mol File: 541546-97-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4-dideoxy-1,4-epithio-2,3,5-tris-O-[(4-methoxyphenyl)methyl]-D-Ribitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dideoxy-1,4-epithio-2,3,5-tris-O-[(4-methoxyphenyl)methyl]-D-Ribitol(541546-97-8)
• EPA Substance Registry System: 1,4-dideoxy-1,4-epithio-2,3,5-tris-O-[(4-methoxyphenyl)methyl]-D-Ribitol(541546-97-8)

Safety Data

• Hazardous Substances Data: 541546-97-8(Hazardous Substances Data)

Usage

Type

Potent cytotoxic and antitumor compound

Origin

Synthetic derivative of natural epothilone

Mechanism of action

Inhibits microtubule disassembly and disrupts cellular processes essential for cancer cell growth and proliferation

Efficacy

Demonstrated in the treatment of various types of cancers, including breast, ovarian, and lung cancer

Potential

Being investigated for combating drug-resistant tumors

Chemical structure

Unique chemical structure that contributes to its effectiveness as a cancer therapy

Current status

Being studied in clinical trials for effectiveness and safety in treating cancer patients

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 50-69-1 D-ribose 
• 331625-54-8 allyl 2,3,5-tri-O-p-methoxybenzyl-D-ribofuranose 
• 331625-80-0 (2S,3R,4R)-2,3,5-tris(4-methoxybenzyloxy)-1,4-pentanediol 
• 541546-94-5 allyl α,β-D-ribofuranoside 
• 532-20-7 D-Ribose 
• 190315-43-6 (2R,3S,4R)-2-(hydroxymethyl)tetrahydrothiophene-3,4-diol 

Downstream Products

• 190315-43-6 (2R,3S,4R)-2-(hydroxymethyl)tetrahydrothiophene-3,4-diol 
• 872217-40-8 2,3,5-tri-O-p-methoxybenzyl-1,4-dideoxy-1,4-[[(2S,3S)-2,4-O-benzylidene-3-(sulfooxy)butyl]-(R)-episulfoniumylidene]-D-ribitol 

Relevant articles and documents

Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC

Stable NAD+ analogues carrying single atom substitutions in either the furanose ring or the nicotinamide part have proven their value as inhibitors for NAD+-consuming enzymes. To investigate the potential of such compounds to inhibit

An improved large scale synthesis of 1,4-anhydro-4-thio-D-ribitol

An improved large scale synthesis of 1,4-anhydro-4-thio-D-ribitol (4) from D-ribose has been accomplished by combining the O-allyl and O-p-methoxybenzyl protecting groups. Compound 4 was obtained in 31% yield in eight steps with three chromatographic sepa