5454-97-7

Basic information

• Product Name: NSC23391
• Synonyms: NSC23391;2-Nitro-N-phenylbenzenesulfonamide
• CAS NO: 5454-97-7
• Molecular Formula: C₁₂H₁₀N₂O₄S
• Molecular Weight: 278.2838
• Mol File: 5454-97-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 115 °C
• Boiling Point: 462°Cat760mmHg
• Flash Point: 233.2°C
• Appearance: /
• Density: 1.461g/cm³
• Vapor Pressure: 1.02E-08mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 7.74±0.10(Predicted)
• CAS DataBase Reference: NSC23391(CAS DataBase Reference)
• NIST Chemistry Reference: NSC23391(5454-97-7)
• EPA Substance Registry System: NSC23391(5454-97-7)

Safety Data

• Hazardous Substances Data: 5454-97-7(Hazardous Substances Data)

Usage

General Description

NSC23391, also known as 2,4-Di-tert-butylphenol, is a chemical compound commonly used as an antioxidant and stabilizer in industrial processes and products such as plastics, adhesives, and lubricants. It is known for its ability to prevent the oxidation and degradation of various materials, particularly those used in the automotive and aerospace industries. NSC23391 is considered to be relatively non-toxic and is not known to have harmful effects on human health or the environment when used in accordance with safety guidelines and regulations. However, like all chemicals, it should be handled and used with caution to minimize potential risks.

InChI:InChI=1/C12H10N2O4S/c15-14(16)11-8-4-5-9-12(11)19(17,18)13-10-6-2-1-3-7-10/h1-9,13H

Upstream product

• 39536-17-9 O-ethyl-N-phenyl-isourea 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 62-53-3 aniline 
• 591-50-4 iodobenzene 
• 5455-59-4 2-Nitrobenzenesulfonamide 

Downstream Products

• 27332-20-3 N-phenyl-2-amino-benzenesulfonamide 
• 23773-71-9 N-methyl-2-nitro-N-phenylbenzenesulfonamide 
• 647035-71-0 (+)-N-nosyl-N-((R)-2-(tert-butyloxycarbonylamino)-2-phenylethyl)benzenamine 
• 838895-17-3 N-phenyl-N-(thietan-3-yl)-2-nitrobenzenesulfonamide 
• 952110-82-6 N-(5-methoxyoct-7-ynyl)-2-nitro-N-phenylbenzenesulfonamide 
• 886845-10-9 3-phenylaminothietane 
• 18127-45-2 2-phenyl-2H-benzo[e][1,2,3,4]thiatriazine-1,1-dioxide 
• 33224-10-1 2-Amino-benzol-sulfon-N-methyl-anilid 
• 1070655-61-6 7-ethyl-1-[2-(4-fluorophenyl)ethyl]-4-phenyl-1,4-diazaperhydroepin-2-one 
• 1172142-57-2 N-(but-3-enyl)-N-phenyl-2-nitrobenzenesulfonamide 
• 1172142-62-9 2-nitro-N-(pent-4-enyl)-N-phenylbenzenesulfonamide 
• 1187670-97-8 ethyl (R)-N-(2-nitrophenylsulfonyl)-N-phenyl-2-aminopropanoate 
• 1235482-00-4 N-(3-(3,6-dibromo-9H-carbazol-9-yl)propyl)-2-nitro-N-phenylbenzenesulfonamide 
• 1235482-01-5 2-nitro-N-(2-(oxiran-2-yl)ethyl)-N-phenylbenzenesulfonamide 

Relevant articles and documents

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

Direct Synthesis of Allyl Amines with 2-Nitrosulfonamide Derivatives via the Tsuji-Trost Reaction

The Tsuji-Trost Reaction is a palladium-catalysed allylation of nucleophiles that consists in the reaction of a nitrogen, carbon or oxygen-based nucleophiles with an allylic substrate bearing a leaving group. Here we present the use of 2-nitrosulfonamide derivatives as nucleophile, which are reactive under mild conditions. 2-nitrosulfonyl groups are well-known dual protective activator groups easy to introduce in any type of amine substrates. The resulting 2-nitrosulfonamide derivatives are ideal substrates for the Tsuji-Trost reaction to afford a convenient and flexible access to primary and dissymmetric secondary allyl amines. The optimised procedure is flexible (for solvent, temperature, functional groups) and has been applied with good to excellent yield to access to a wide range of allyl amine derivatives.

Transition-Metal-Free Tandem Cyclization/ N-Arylation Reaction: A Method to Access Biaryl Sultam Derivatives via a Diradical Pathway

A novel procedure for the transition-metal-free tandem cyclization/N-arylation reaction sequence of an aryne with a 1,2,3,4-benzothiatriazine-1,1-dioxide is reported. This reaction goes through the intramolecular homolytic cyclization to generate an N-H b