549500-24-5

Basic information

• Product Name: N-(2-benzoylphenyl)propanamide
• Synonyms: N-(2-benzoylphenyl)propanamide
• CAS NO: 549500-24-5
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.299
• Mol File: 549500-24-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 83-84 °C
• Boiling Point: 483.7±28.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• PKA: 14.54±0.70(Predicted)
• CAS DataBase Reference: N-(2-benzoylphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-benzoylphenyl)propanamide(549500-24-5)
• EPA Substance Registry System: N-(2-benzoylphenyl)propanamide(549500-24-5)

Safety Data

• Hazardous Substances Data: 549500-24-5(Hazardous Substances Data)

Upstream product

• 123-62-6 propionic acid anhydride 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 79-03-8 propionyl chloride 
• 690661-10-0 heptanoic acid (2-benzoyl-phenyl)-amide 
• 620-71-3 N-(phenyl)-2-methylacetamide 
• 108-88-3 toluene 
• 100-52-7 benzaldehyde 
• 60751-75-9 N-(2-iodophenyl)propionamide 

Downstream Products

• 107288-91-5 2-ethyl-4-phenylquinazoline 
• 5260-41-3 2-ethyl-3-phenyl-3H-quinazolin-4-one 
• 78825-91-9 2-ethyl-3-phenyl-1H-indole 
• 37118-75-5 3-methyl-4-(phenyl)-2-(1H)-quinolinone 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 88795-69-1 1-Ethyl-3-methyl-4-phenyl-1H-quinolin-2-one 
• 690661-10-0 heptanoic acid (2-benzoyl-phenyl)-amide 

Relevant articles and documents

Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones

Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.

Palladium-catalyzed direct ortho -acylation through an oxidative coupling of acetanilides with toluene derivatives

A facile ortho-acylation of acetanilides by a Pd-catalyzed oxidative C-H activation was developed in which low toxic, stable, and commercially available toluene derivatives were first used as acylation reagents by a tandem reaction to form o-acylacetanili