88795-69-1

Basic information

• Product Name: 2(1H)-Quinolinone, 1-ethyl-3-methyl-4-phenyl-
• CAS NO: 88795-69-1
• Molecular Formula: C18H17NO
• Molecular Weight: 263.339
• Mol File: 88795-69-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinolinone, 1-ethyl-3-methyl-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone, 1-ethyl-3-methyl-4-phenyl-(88795-69-1)
• EPA Substance Registry System: 2(1H)-Quinolinone, 1-ethyl-3-methyl-4-phenyl-(88795-69-1)

Safety Data

• Hazardous Substances Data: 88795-69-1(Hazardous Substances Data)

Upstream product

• 10266-13-4 2,4-Diphenyl-3-methylquinoline 
• 690661-10-0 heptanoic acid (2-benzoyl-phenyl)-amide 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 549500-24-5 N-(2-benzoylphenyl)propionamide 
• 75-03-6 ethyl iodide 

Relevant articles and documents

Facile synthesis of 4-phenylquinolin-2(1H)-one derivatives from N-acyl-o-aminobenzophenones

An efficient synthesis of 4-phenylquinolin-2(1H)-one derivatives has been achieved in a one-pot reaction from N-acyl-o-aminobenzophenones 1a-c (a: acyl=acetyl; b: acyl=propanoyl; c: acyl=heptanoyl) using NaH as a base. Treatment of 1 with NaH provided the quinolones 2a-c with 62-83% yields, whereas the reaction in the presence of alkyl iodide (alkyl=methyl, ethyl, n-octyl) gave the corresponding N-alkylated quinolones 3a-g in 75-95% yields. The alkylation reaction of 4-phenylquinolin-2(1H)-one 2a with alkyl halide gave a mixture of N-alkylated and O-alkylated products. Comparison of IR and NMR data of the N-alkylated and O-alkylated compounds with those of 2a-c indicated that 2a-c exist as the lactam form.