550358-40-2

Basic information

• Product Name: benzyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]carbamate
• Synonyms: benzyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]carbamate
• CAS NO: 550358-40-2
• Molecular Weight: 299.326
• Mol File: 550358-40-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]carbamate(550358-40-2)
• EPA Substance Registry System: benzyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]carbamate(550358-40-2)

Safety Data

• Hazardous Substances Data: 550358-40-2(Hazardous Substances Data)

Upstream product

• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 550358-42-4 ethyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]-2-(2,2-dichlorovinyl)-5,6-dimethoxybenzimidate 
• 550358-41-3 N-[2-(benzo[1,3]dioxol-5-yl)ethyl]-2-(2,2-dichlorovinyl)-5,6-dimethoxybenzamide 
• 550358-44-6 ethyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]-2-ethynyl-5,6-dimethoxybenzimidate 
• 223674-20-2 N-[2-(benzo[1,3]dioxol-5-yl)ethyl]-2-ethynyl-5,6-dimethoxybenzamide 
• 71700-15-7 12b-hydroxy-9,10-dimethoxy-5H-[1,3]dioxolo[4'',5'':4',5']benzo[1',2':4,5]azepino[2,1-a]isoindole-8,13(6H,12bH)-dione 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 

Relevant articles and documents

Preparation method of aporphine alkaloid

The invention discloses a preparation method of aporphine alkaloid as shown in a formula III. The method comprises the following steps: taking a benzaldehyde compound as shown in a formula III-0 as a raw material, and sequentially carrying out Wittig reaction, Pictet-Spengler reaction, Heck reaction and palladium carbon hydrogen deprotection. A bromine-containing benzaldehyde derivative is selected as a raw material, the carbon-carbon coupling co-production rate and the reaction rate are increased through bromine atoms, and the reaction activity is improved; benzyl chloroformate is adopted for NH protection, and an electron withdrawing group is introduced, so that the reaction yield can be improved; and a styrene methyl ether derivative directly reacts with an acylated phenylethylamine derivative in an acid catalysis system by adopting a one-pot method so as to obtain benzyl tetrahydroisoquinoline. The preparation method has the advantages of mild reaction conditions, low toxicity of used reagents, easily available raw materials, convenient post-treatment and simpler reaction route compared with previous reports, and can be suitable for various reaction substrates.

Total synthesis of lennoxamine and chilenine via ring-expansion of isoindoloisoquinoline to isoindolobenzazepine

Convenient synthesis of the benzazepine alkaloids, lennoxamine (1) and chilenine (2), is described. The key steps are conversion of methylenelactam (5) to an N-tertiary acyliminium ion precursor (16) and a novel expansion of the six-membered ring of 4 to a benzazepine ring system (3b), which could be transformed into lennoxamine (1) and chilenine (2).