550358-41-3Relevant articles and documents
Total synthesis of lennoxamine and chilenine via ring-expansion of isoindoloisoquinoline to isoindolobenzazepine
Koseki, Yuji,Katsura, Shinya,Kusano, Shuichi,Sakata, Harumi,Sato, Hiroto,Monzene, Yoshinori,Nagasaka, Tatsuo
, p. 527 - 540 (2007/10/03)
Convenient synthesis of the benzazepine alkaloids, lennoxamine (1) and chilenine (2), is described. The key steps are conversion of methylenelactam (5) to an N-tertiary acyliminium ion precursor (16) and a novel expansion of the six-membered ring of 4 to a benzazepine ring system (3b), which could be transformed into lennoxamine (1) and chilenine (2).