5606-55-3

Basic information

• Product Name: ethyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate
• Synonyms: ethyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate;7-Chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid ethyl ester
• CAS NO: 5606-55-3
• Molecular Formula: C₁₈H₁₅ClN₂O₃
• Molecular Weight: 342.7763
• EINECS: 227-026-7
• Mol File: 5606-55-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 506.7°C at 760 mmHg
• Flash Point: 260.2°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 2.18E-10mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: ethyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate(5606-55-3)
• EPA Substance Registry System: ethyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate(5606-55-3)

Safety Data

• Hazardous Substances Data: 5606-55-3(Hazardous Substances Data)

Usage

General Description

Ethyl 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate, also known as clonazepam, is a medication and psychoactive drug that belongs to the benzodiazepine class. It is commonly used to treat anxiety, panic disorder, and seizures. Clonazepam works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which helps to reduce anxiety and seizures. However, it also has the potential for abuse and dependence, and should only be used under the guidance of a healthcare professional. This chemical is available in various forms including tablets, orally disintegrating tablets, and oral solution, and it is typically taken two or three times daily. Side effects may include drowsiness, dizziness, and confusion, and it should not be used with alcohol or other central nervous system depressants.

InChI:InChI=1/C18H15ClN2O3/c1-2-24-18(23)16-17(22)20-14-9-8-12(19)10-13(14)15(21-16)11-6-4-3-5-7-11/h3-10,16H,2H2,1H3,(H,20,22)

Upstream product

• 62538-78-7 ethyl 2'-benzoyl-4'-chloro-mesoxalanilate 2-oxime 

Downstream Products

• 88369-18-0 7-chloro-3-(ethoxycarbonyl)-5-phenyl-<3-2H₁>-1,3-dihydro-2H-1,4-benzodiazepin-2-one 
• 35142-51-9 10-chloro-11b-phenyl-2,3,5,11b-tetrahydrooxazolo[3,2-d] [1,4]benzodiazepin-6(7H)-one-5-carboxylic acid ethyl ester 
• 353524-67-1 C₁₈H₁₅ClN₂O₃ 
• 78817-83-1 C₁₈H₁₅ClN₂O₃ 
• 61294-98-2 7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid isopropyl ester 
• 88369-21-5 C₂₃H₁₈⁽²⁾HClN₂O₄S 
• 88369-19-1 7-chloro-5-phenyl-3-hydroxymethyl-3-deuterio-1,3-dihydro-2H-1,4-benzodiazepin-2-one 
• 88369-22-6 7-chloro-5-phenyl-3-methyl-2,2,3,3'-tetradeuterio-1,3-dihydro-2H-1,4-benzodiazepine 
• 88369-23-7 7-chloro-5-phenyl-3-methyl-3-deuterio-1,3-dihydro-2H-1,4-benzodiazepine 
• 317802-20-3 5-phenyl-7-chloro-3-benzyl-3-hydroxymethyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 
• 317802-17-8 5-phenyl-7-chloro-3-benzyl-3-ethoxycarbonyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one 
• 213753-67-4 7-Chloro-3-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid ethyl ester 
• 27017-01-2 7-chloro-3-hydroxymethyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 

Relevant articles and documents

Preparation of benzodiazepine derivatives

A process for the manufacture of benzodiazepine derivatives which comprises reacting 2-amino-5-chloro-benzophenone with a primary amine H2 N--R1 to give an imine which is reacted with an amino-ester STR1 to give a ketimine said ketimine being then converted to a benzodiazepine derivative.

Intermediates for preparing 1,4-benzodiazepine-2-ones having a carboxylic acid ester or amide group in the 3-position

Intermediates for preparing novel benzodiazepines having the formula SPC1 In which R1 is a hydrogen or halogen atom or a trifluoromethyl, loweralkyl, loweralkoxy, nitro or amino group; R2 is a furyl, a thienyl, cyclohexyl, a loweralkyl group or a phenyl group which may be substituted by a halogen atom or by a trifluoromethyl, nitro, loweralkoxy or loweralkyl group; and R3 is a hydrogen atom or a loweralkyl group; and R4 is lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)carbamoyl, a group having the formula --COOCat in which Cat is a cation of an alkali metal or a semication of an alkaline earth metal or COOCat.CatOH, said intermediates being ortho-aminoaryl ketimines having the formula SPC2 Wherein R is hydrogen or EQU1 R1, R2, and R3 are as defined above, R4 is a hydrogen atom, a lowercarbalkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl, N-(diloweralkylaminoalkyl)-carbamoyl, alkyl or substituted alkyl group; and R5 is a loweralkyl group.