5728-12-1

Basic information

• Product Name: 1,2,5-Thiadiazol-3(2H)-one, 4-phenyl-
• CAS NO: 5728-12-1
• Molecular Formula: C8H6N2OS
• Molecular Weight: 178.214
• Mol File: 5728-12-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,2,5-Thiadiazol-3(2H)-one, 4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Thiadiazol-3(2H)-one, 4-phenyl-(5728-12-1)
• EPA Substance Registry System: 1,2,5-Thiadiazol-3(2H)-one, 4-phenyl-(5728-12-1)

Safety Data

• Hazardous Substances Data: 5728-12-1(Hazardous Substances Data)

Usage

Chemical class

Thiadiazole derivatives

Common use

Building block in the synthesis of pharmaceutical compounds and agrochemicals

Biological activities

Anti-inflammatory, anti-tumor, and anti-bacterial

Preclinical studies

Shown potential as an agent in various biological activities

Structure and reactivity

Unique, making it an important intermediate in the production of advanced materials and fine chemicals

Investigation

Potential application in the development of new drugs for the treatment of various diseases

Upstream product

• 32153-16-5 2-(benzylamino)-2-phenylacetamide 
• 100-52-7 benzaldehyde 
• 700-63-0 Phenylglycinamid 
• 32153-18-7 2-(benzylamino)-2-phenylacetonitrile 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 102-04-5 1,3-Diphenylpropanone 

Downstream Products

• 37033-85-5 3-oxiranylmethoxy-4-phenyl-[1,2,5]thiadiazole 
• 412274-19-2 2-(3-chloro-2-hydroxy-propyl)-4-phenyl-[1,2,5]thiadiazol-3-one 
• 37033-77-5 2-(3-tert-butylamino-2-hydroxy-propyl)-4-phenyl-[1,2,5]thiadiazol-3-one 
• 37033-76-4 2-(2-hydroxy-3-isopropylamino-propyl)-4-phenyl-[1,2,5]thiadiazol-3-one 
• 105689-20-1 Methyl 3-Phenyl-4-acetoamidoisothiazole-5-carboxylate 
• 105689-21-2 3-Phenyl-4-acetoamidoisothiazole-5-carboxylic acid 
• 105689-19-8 3-Phenyl-5-methylisothiazolo<5,4-e>-3,4-dihydropyrimidin-4-one 
• 105689-18-7 3-Phenyl-4-(diacetyl)aminoisothiazole 
• 82424-75-7 3-Phenyl-4-aminoisothiazole-5-carboxylic acid 
• 105689-22-3 3-Phenyl-4-aminoisothiazole 
• 69643-34-1 3-(4-chloro-phenyl)-4-phenyl-[1,2,5]thiadiazole 
• 151133-39-0 3-Bromo-4-phenyl-[1,2,5]thiadiazole 
• 105689-23-4 3-Phenyl-4-(1'-propionyl)amino-5-methylisothiazole 
• 20459-06-7 3-Phenyl-4-acetoxyisothiazole 

Relevant articles and documents

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Sulfamates as antiglaucoma agents

Sulfamate esters of the formula where A is aryloxyalkyl, p is the number of unreacted hydroxy groups present on the alkyl moiety and may be zero, z is the number of --OS(O)2 NR1 R2 groups attached to carbons of the alkyl moiety and is always at least one; R1 and R2 are selected from hydrogen, loweralkyl, carboxy, and the like are useful in treating glaucoma.

FACILE SYNTHESIS OF 3-OXO-1,2,5-THIADIAZOLES; 7β-CEPHALOSPHORINS

A simple procedure is described for the preparation of 3-oxo-1,2,5-thiadiazoles under mild conditions.This procedure has provided hitherto unknown 7β-3-oxo-1,2,5-thiadiazol-2-yl)cephalosporins.