58443-83-7

Basic information

• Product Name: 1-(4-acetylphenyl)propan-2-one
• Synonyms: 1-(4-acetylphenyl)propan-2-one
• CAS NO: 58443-83-7
• Molecular Weight: 176.215
• Mol File: 58443-83-7.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1-(4-acetylphenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-acetylphenyl)propan-2-one(58443-83-7)
• EPA Substance Registry System: 1-(4-acetylphenyl)propan-2-one(58443-83-7)

Safety Data

• Hazardous Substances Data: 58443-83-7(Hazardous Substances Data)

Upstream product

• 108-22-5 Isopropenyl acetate 
• 99-90-1 para-bromoacetophenone 
• 15435-71-9 sodium acetylacetonate 
• 13329-40-3 4-Iodoacetophenone 
• 123-54-6 acetylacetone 
• 350-47-0 1-(4-acetylphenyl)diazonium tetrafluoroborate 
• 99-92-3 p-aminobenzophenone 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 99-91-2 para-chloroacetophenone 
• 67-64-1 acetone 
• 1198184-14-3 C₁₁H₁₀N₂O₄S 
• 32783-20-3 benzyl isopropenyl ether 
• 2117-39-7 benzylmercury(II) chloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 753401-45-5 N-[2-(4-[1-hydroxy-1-ethyl]phenyl)-1-methylethyl]-2-hydroxy-2-phenylethanamine 

Relevant articles and documents

UiO-66 microcrystals catalyzed direct arylation of enol acetates and heteroarenes with aryl diazonium salts in water

UiO-66 is a classic Metal–organic framework (MOF) that constructed by zirconium cations and terephthalate with high chemical and thermal stability. Using pristine UiO-66 nanocrystals as the catalysts, the carbon–carbon bond formation based on denitrogenat

Salicylic Acid-Catalyzed Arylation of Enol Acetates with Anilines

α-Aryl ketones are both structure moieties commonly found in bioactive compounds and versatile synthetic intermediates for the preparation of drug-like molecules. An operationally simple and scalable protocol has been developed to prepare α-aryl ketones from readily available aromatic amines and enol acetates (or silyl enol ethers). This metal-free methodology features the use of salicylic acid as a convenient catalyst to promote the formation of aryl radicals from in-situ generated aryl diazonium salts, without demanding thermal or photochemical activation. The mild reaction conditions used are compatible with anilines substituted with diverse functionalities. Structural elaboration of some prepared α-aryl ketones was accomplished to illustrate their usefulness as building blocks. (Figure presented.).

Design of an Indolylphosphine Ligand for Reductive Elimination-Demanding Monoarylation of Acetone Using Aryl Chlorides

The rational design of a phosphine ligand for the reductive elimination-demanding Pd-catalyzed mono-α-arylation of acetone is demonstrated and reported. The catalyst is tolerant of previously proven challenging electron-deficient aryl chlorides and provides excellent product yields with down to 0.1 mol % Pd. Preliminary investigations suggest that the rate-limiting step for the proposed system is the oxidative addition of aryl chlorides, in which it contradicts previous findings regarding the α-arylation of acetone with aryl halides.