588-95-4

Basic information

• Product Name: 4-FLUOROBENZALDEHYDE OXIME
• Synonyms: 4-FLUOROBENZALDOXIME;4-FLUOROBENZALDEHYDE OXIME;(Z)-p-fluorobenzaldehyde oxime;(Z)-4-Fluorobenzaldehyde oxime;Einecs 209-628-1
• CAS NO: 588-95-4
• Molecular Formula: C₇H₆FNO
• Molecular Weight: 139.13
• EINECS: 209-628-1
• Product Categories: Fluorine Compounds
• Mol File: 588-95-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 82-85 °C(lit.)
• Boiling Point: 194.9 °C at 760 mmHg
• Flash Point: 71.7 °C
• Appearance: /
• Density: 1.14 g/cm³
• PKA: 11.18±0.10(Predicted)
• CAS DataBase Reference: 4-FLUOROBENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZALDEHYDE OXIME(588-95-4)
• EPA Substance Registry System: 4-FLUOROBENZALDEHYDE OXIME(588-95-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: CU6260000
• Hazardous Substances Data: 588-95-4(Hazardous Substances Data)

Usage

General Description

4-Fluorobenzaldehyde oxime is a chemical compound that is derived from fluorobenzaldehyde and hydroxylamine. It is commonly used as a reagent in organic synthesis and as a building block in the production of various pharmaceuticals and agrochemicals. 4-FLUOROBENZALDEHYDE OXIME has a wide range of applications, including as an intermediate in the synthesis of dyes, perfumes, and other organic compounds. It also exhibits potential for use in medicinal chemistry, particularly in the development of inhibitors for certain enzymes and receptors. Additionally, its properties make it suitable for use as a chelating agent in metal extraction processes and as a reagent in analytical chemistry. Overall, 4-Fluorobenzaldehyde oxime is a versatile compound with diverse uses in both the industrial and research sectors.

InChI:InChI=1/C7H6FNO/c8-7-3-1-6(2-4-7)5-9-10/h1-5,10H/b9-5+

Upstream product

• 459-23-4 (E)-4-fluorobenzaldehyde oxime 
• 459-57-4 4-fluorobenzaldehyde 
• 18861-57-9 ethyl (E)-2-cyano-3-(4-fluorophenyl)-2-propenoate 

Downstream Products

• 459-23-4 (E)-4-fluorobenzaldehyde oxime 
• 1194-02-1 4-fluorobenzonitrile 
• 753479-66-2 [3-(4-fluorophenyl)isoxazol-5-yl]methyl acetate 
• 393165-20-3 (Z)-N-hydroxy-4-fluoro-benzenecarboximidoyl chloride 
• 1056189-40-2 4-fluorobenzohydroximoyl chloride 
• 253443-43-5 5-(chloromethyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole 

Relevant articles and documents

Visible-light mediated stereospecific C(sp2)-H difluoroalkylation of (Z)-aldoximes

A visible light mediated stereospecific C(sp2)-H difluoroalkylation of (Z)-aldoximes to (E)-difluoroalkylated ketoximes has been described. In this reaction, (hetero)-aromatic and aliphatic difluoroalkylated ketoximes could be obtained with the retention of the configuration of the starting aldoximes. A preliminary mechanism study showed that a difluoromethyl radicalviaan SET pathway was involved.

ISOXAZOLO-PYRIDAZINE DERIVATIVES

The invention relates to isoxazolo-pyridazine compounds, in particular those of formula I as described above and to a pharmaceutically acceptable salts thereof, having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for the treatment of cognitive disorders like Alzheimer's disease.

X=Y-ZH systems as potential 1,3-dipoles. Part 56: Cascade 1,3-azaprotio cyclotransfer-cycloaddition reactions between aldoximes and divinyl ketone: The effect of oxime E/Z isomerism on cycloaddition stereoselectivity

The cascade 1,3-azaprotiocyclotransfer (1,3-APT)-1,3-dipolar-cycloaddition (1,3-DC) reaction between aldoximes and divinyl ketone affords mixtures of exo and endo-isomers of substituted 1-aza-7-oxabicyclo[3.2.1]octan-4-ones, the ratio of which is dependent on the E/Z geometry of the starting oxime and its ability to isomerise under the thermal reaction conditions.