59101-28-9Relevant articles and documents
Pachychalines A-C: Novel 3-alkylpyridinium salts from the marine sponge Pachychalina sp.
Laville, Remi,Thomas, Olivier P.,Berrue, Fabrice,Reyes, Fernando,Amade, Philippe
, p. 121 - 125 (2008)
Three 3-alkylpyridinium salts, pachychalines A (1), B (2) and C (3), were isolated from the Caribbean marine sponge Pachychalina sp. (order Haplosclerida). They are the first examples of 3-(aminoalkyl)pyridinium salts. Their chemical structures were elucidated by NMR spectroscopy and detailed ESI HRMS-MS analysis. The total synthesis of 1 allowed the confirmation of the unusual C-C connection between both pyridinium moieties. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Scalable Synthesis of Human Ultralong Chain Ceramides
Opálka, Luká?,Ková?ik, Andrej,Sochorová, Michaela,Roh, Jaroslav,Kune?, Ji?í,Len?o, Juraj,Vávrová, Kate?ina
supporting information, p. 5456 - 5459 (2015/11/18)
Ceramides with ultralong chains (≥30 carbons), also known as acylceramides, play a critical role in the survival of mammals on dry land. An efficient and scalable synthesis of four major classes of ultralong human skin ceramides is reported. The key approach involves the use of a succinimidyl ester that acts as a protective group, helps overcome the extremely low solubility, and simultaneously activates the fatty acid for its clean and high-yielding attachment to a sphingoid base.
Synthesis of new ligands for targeting the S1P1 receptor
Schilson, Stefanie S.,Keul, Petra,Shaikh, Rizwan S.,Sch?fers, Michael,Levkau, Bodo,Haufe, Günter
, p. 1011 - 1026 (2015/03/04)
Sphingosine-1-phosphate (S1P) influences various fundamental biological processes by interacting with a family of five G protein-coupled receptors (S1P1-5). FTY720, a sphingosine analogue, which was approved for treatment of relapsing forms of multiple sclerosis, is phosphorylated in vivo and acts as an agonist of four of the five S1P receptor subtypes. Starting from these lead structures we developed new agonists for the S1P1 receptor. The biological activity was tested in vivo and promising ligands were fluorinated at different positions to identify candidates for positron emission tomography (PET) imaging after [18F]-labelling. The radioligands shall enable the imaging of S1P1 receptor expression in vivo and thus may serve as novel imaging markers of S1P-related diseases.