6048-21-1

Basic information

• Product Name: 4-BROMOBENZOYL CYANIDE
• Synonyms: 4-BROMOBENZOYL CYANIDE
• CAS NO: 6048-21-1
• Molecular Formula: C₈H₄BrNO
• Molecular Weight: 210.03
• Mol File: 6048-21-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 67℃
• Boiling Point: 277.4±23.0℃ (760 Torr)
• Flash Point: 121.6±22.6℃
• Appearance: /
• Density: 1.609±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: 4-BROMOBENZOYL CYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOBENZOYL CYANIDE(6048-21-1)
• EPA Substance Registry System: 4-BROMOBENZOYL CYANIDE(6048-21-1)

Safety Data

• Hazardous Substances Data: 6048-21-1(Hazardous Substances Data)

Usage

General Description

4-Bromobenzoyl cyanide, also known as 4-Cyanobenzoyl bromide, is a chemical compound with the molecular formula C8H4BrNO. It is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents. 4-Bromobenzoyl cyanide is primarily used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is a versatile building block for the preparation of various organic compounds, including dyes, pigments, and herbicides. Additionally, it is used in the manufacture of certain polymers and as a precursor in the synthesis of other chemical compounds. However, it is important to handle 4-Bromobenzoyl cyanide with caution, as it is potentially hazardous and should be used in a well-ventilated area while wearing appropriate personal protective equipment.

Upstream product

• 108-86-1 bromobenzene 
• 1115-12-4 carbonyl cyanide 
• 5195-29-9 4-bromophenylglyoxal 
• 99-73-0 para-bromophenacyl bromide 
• 7677-24-9 trimethylsilyl cyanide 
• 586-75-4 4-chlorobenzoyl chloride 
• 544-92-3 copper(I) cyanide 
• 151-50-8 potassium cyanide 
• 2179-92-2 tri-n-butyltin cyanide 
• 748166-19-0 1-bromo-4-(1-bromoamino)toluene 
• 16532-79-9 4-Bromophenylacetonitrile 
• 74-90-8 hydrogen cyanide 
• 1122-91-4 4-bromo-benzaldehyde 
• 58289-69-3 2-(4-bromophenyl)-2-hydroxyacetonitrile 

Downstream Products

• 69374-79-4 2-(4-bromophenyl)-2-oxoacetamide 
• 74-90-8 hydrogen cyanide 
• 25938-97-0 4-bromo-N'-phenylbenzohydrazide 
• 698-67-9 p-bromobenzamide 
• 6846-12-4 4-bromo-N-phenyl-benzamide 
• 35578-47-3 4,4'-dibromobenzil 
• 378186-96-0 1-(4-bromophenyl)-2,3-butadien-1-one 
• 184165-64-8 1-(4-bromophenyl)-3-buten-1-one 
• 4592-94-3 3-(4-bromophenyl)-3-oxopropanenitrile 
• 78271-77-9 3-(4-bromophenyl)-2-methyl-3-oxopropanenitrile 
• 4023-81-8 1-(p-bromophenyl)-1,3-butanedione 
• 57699-28-2 methyl 4-bromophenylglyoxalate 
• 57699-35-1 cis-2,3-bis(carbomethoxy)-p,p'-dibromostilbene oxide 
• 81316-42-9 trans-2,3-bis(carbomethoxy)-p,p'-dibromostilbene oxide 

Relevant articles and documents

A Cyanide-Free Synthesis of Acylcyanides through Ru-Catalyzed C(sp3)-H-Oxidation of Benzylic Nitriles

A practical method for generation of acylcyanides devoid of any external cyanide sources is presented that relies on a mild Ru-catalyzed selective C?H-oxidation of benzylic nitriles. The starting materials are smoothly generated through condensation of the corresponding carboxylic acid amides using silanes. The obtained acylcyanides can be employed in a plethora of transformation as exemplified to some larger extend in the sequence of C?H-oxidation-Tischenko-rearrangement for the generation of structurally diverse benzoyloxycyanohydrines.

Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes

A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.

Synthesis of benzoyl cyanide through aerobic photooxidation of benzyl cyanide using carbon tetrabromide as a catalyst

We developed a synthetic method toward benzoyl cyanide through aerobic photooxidation of benzyl cyanide in the presence of carbon tetrabromide under visible light irradiation with fluorescent lamps.