60774-46-1

Basic information

• Product Name: Cyclohexanone, 4-(1,1-dimethylethyl)-2-(phenylthio)-
• CAS NO: 60774-46-1
• Molecular Formula: C16H22OS
• Molecular Weight: 262.416
• Mol File: 60774-46-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 4-(1,1-dimethylethyl)-2-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(1,1-dimethylethyl)-2-(phenylthio)-(60774-46-1)
• EPA Substance Registry System: Cyclohexanone, 4-(1,1-dimethylethyl)-2-(phenylthio)-(60774-46-1)

Safety Data

• Hazardous Substances Data: 60774-46-1(Hazardous Substances Data)

Upstream product

• 1076-82-0 2-bromo-4-tert-butylcyclohexanone 
• 108-98-5 thiophenol 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 19980-19-9 4-t-butyl-1-trimethylsilyloxy-1-cyclohexene 
• 60774-46-1 trans-4-(1,1-dimethylethyl)-2-(methylthio)cyclohexanone 
• 136067-94-2 2‐(methylsulfanyl)‐1‐[4‐(trifluoromethyl)phenyl]ethanone 
• 5398-93-6 2-methylthio-1-phenyl-ethanone 
• 24437-53-4 1-(4-chlorophenyl)-2-methylthio ethanone 
• 46188-84-5 1‐(4‐methoxyphenyl)‐2‐(methylsulfanyl)ethanone 
• 624-92-0 Dimethyldisulphide 
• 1114817-69-4 2-(methylthio)-1-(4-cyanophenyl)-1-ethanone 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 882-33-7 diphenyldisulfane 
• 60774-46-1 cis-4-tert-Butyl-2-phenylthiocyclohexanone 

Downstream Products

• 110977-10-1 (2RS,4RS)-4-tert-butyl-2-methyl-2-phenylthiocyclohexanone 
• 110977-10-1 (2RS,4SR)-4-tert-butyl-2-methyl-2-phenylthiocyclohexanone 
• 60774-46-1 trans-4-(1,1-dimethylethyl)-2-(methylthio)cyclohexanone 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 1114817-79-6 p-cyano-α,α-di(methylthio)acetophenone 
• 62151-61-5 (2RS,4SR)-4-(tert-butyl)-2-(methylthio)cyclohexanone 
• 60774-46-1 cis-4-tert-Butyl-2-phenylthiocyclohexanone 
• 108920-15-6 (2RS,4RS)-4-(tert-butyl)-2-(methylthio)cyclohexanone 
• 21875-72-9 1-(4-methoxy-phenyl)-2-phenylsulfanyl-ethanone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 99-91-2 para-chloroacetophenone 
• 171897-88-4 p-chlorophenyl di(methylthio)methyl ketone 
• 16222-10-9 1-phenyl-2-(phenylthio)ethanone 
• 98-86-2 acetophenone 

Relevant articles and documents

Disulfide-based metal-free α-sulfanylation of ketones

An eco-friendly methodology for the direct α-sulfanylation of ketones, has been developed. The procedure, based on the use of functionalized diaryldisulfides and catalyzed by d,l-proline, represents a mild and efficient approach for the preparation of α-arylthio-ketones.

Nucleophilic substitution reactions of sulfur-substituted cyclohexanone acetals: An analysis of the factors controlling stereoselectivity

The reactions of cyclohexanone acetals substituted with thiophenyl groups (and other heteroatoms) at C-2 demonstrate the powerful influence that these substituents have on the stereoselectivity of nucleophilic substitution reactions. The trans selectivities of these reactions correlate with the behavior of the corresponding ketones. These experiments lend support to the possibility that the reactions of the acetals, which proceed via oxocarbenium ions, are operating under Felkin-Anh control.

Alkyl Migration in Competition with Phenylthio Migration in the Acid-catalysed Rearrangement of Alcohols

Sulfonate derivatives of conformationally rigid syn-2-phenylthiocyclohexanols, which are prevented from phenylthio migration by stereochemistry, rearrange slowly by alkyl migration or ring contraction.In contrast to other electronegative groups, phenylthio slows the reaction down but allows migration of other groups.