632352-60-4

Basic information

• Product Name: TERT-BUTYL 4-AMINO-3-PHENYLPIPERIDINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 4-AMINO-3-PHENYLPIPERIDINE-1-CARBOXYLATE;tert-Butyl 4-amino-3-phenyl-1-piperidinecarboxylate
• CAS NO: 632352-60-4
• Molecular Formula: C₁₆H₂₄N₂O₂
• Molecular Weight: 276.37396
• Mol File: 632352-60-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL 4-AMINO-3-PHENYLPIPERIDINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-AMINO-3-PHENYLPIPERIDINE-1-CARBOXYLATE(632352-60-4)
• EPA Substance Registry System: TERT-BUTYL 4-AMINO-3-PHENYLPIPERIDINE-1-CARBOXYLATE(632352-60-4)

Safety Data

• Hazardous Substances Data: 632352-60-4(Hazardous Substances Data)

Upstream product

• 1271738-27-2 4-(hydroxyimino)-3-phenylpiperidine-1-carboxylic acid tert-butyl ester 
• 632352-56-8 (±)-tert-butyl 4-oxo-3-phenylpiperidine-1-carboxylate 
• 446302-83-6 1-N-benzyl-3-phenyl-4-piperidone 
• 1384264-55-4 C₂₁H₂₃NO₃ 
• 1345345-81-4 1-benzyl-3-phenyl-4-piperidone hydrochloride 
• 910875-39-7 4-oxo-3-phenylpiperidine hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 108-86-1 bromobenzene 

Downstream Products

• 874361-08-7 4-benzoylamino-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester 
• 874361-10-1 4-(2,2-dimethyl-propionylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES

Disclosed are compounds of Formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6,R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula (1), to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists

We synthesized a series of novel 3-phenyl-4-benzylaminopiperidine derivatives that were identified as potent tachykinin NK1 receptor antagonists by structural modification of the 3-benzhydrylpiperidone derivative through high-throughput screening. N-{2-[(3R,4S)-4-({2-Methoxy-5-[5-(trifluoromethyl)- 1Htetrazol-1-yl]benzyl}amino)-3-phenyl-1-piperidinyl]-2-oxoethyl}acetamide ((+)-39) was found to be one of the most potent tachykinin NK1 receptor antagonists with high metabolic stability. Highly efficient asymmetric synthesis of (+)-39 was achieved via dynamic kinetic resolution.

PIPERIDINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a compound represented by the formula: ???wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, R1 is a hydrogen atom, an optionally substituted hydroca