64506-21-4

Basic information

• Product Name: (+/-)-2-methyl-3-(p-methoxyphenyl)propanol
• Synonyms: (+/-)-2-methyl-3-(p-methoxyphenyl)propanol
• CAS NO: 64506-21-4
• Molecular Weight: 180.247
• Mol File: 64506-21-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (+/-)-2-methyl-3-(p-methoxyphenyl)propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-2-methyl-3-(p-methoxyphenyl)propanol(64506-21-4)
• EPA Substance Registry System: (+/-)-2-methyl-3-(p-methoxyphenyl)propanol(64506-21-4)

Safety Data

• Hazardous Substances Data: 64506-21-4(Hazardous Substances Data)

Upstream product

• 5689-72-5 4-p-methoxyphenyl-5-methyl-1,3-dioxane 
• 105-13-5 4-Methoxybenzyl alcohol 
• 67-56-1 methanol 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 20849-82-5 1-methoxy-4-(2-methylallyl)benzene 
• 52750-06-8 ethyl 2-methyl-3-[4-(methoxy)phenyl]propanoate 
• 52750-05-7 3-(4-methoxy-phenyl)-2-methyl-acrylic acid ethyl ester 
• 108-82-7 2,6-dimethyl-4-heptanol 

Downstream Products

• 1393109-65-3 tert-butyl-[3-(4-methoxyphenyl)-2-methylpropoxy]dimethylsilane 
• 79253-39-7 (S)-(-)-3-(4-methoxyphenyl)-2-methylpropan-1-ol 
• 262849-39-8 (2S)-1-acetoxy-2-methyl-3-p-methoxyphenylpropane 
• 5462-06-6 3-(p-methoxyphenyl)-2-methylpropionaldehyde 

Relevant articles and documents

Ru-Catalyzed Selective Catalytic Methylation and Methylenation Reaction Employing Methanol as the C1 Source

Methanol can be employed as a green and sustainable methylating agent to form C-C and C-N bonds via borrowing hydrogen (BH) methodology. Herein we explored the activity of the acridine-derived SNS-Ru pincer for the activation of methanol to apply it as a C1 building block in different reactions. Our catalytic system shows great success toward the β-C(sp3)-methylation reaction of 2-phenylethanols to provide good to excellent yields of the methylated products. We investigated the mechanistic details, kinetic progress, and temperature-dependent product distribution, which revealed the slow and steady generation of in situ formed aldehyde, is the key factor to get the higher yield of the β-methylated product. To establish the environmental benefit of this reaction, green chemistry metrics are calculated. Furthermore, dimerization of 2-naphthol via methylene linkage and formation of N-methylation of amine are also described in this study, which offers a wide range of substrate scope with a good to excellent yield.

Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates

Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive SN2-like oxidative addition of a nickel complex to the electrophilic substrate.

Chemoenzymatic synthesis of (+)-α-polypodatetraene and methyl (5R,10R,13R)-labda-8-en-15-oate

The reported enzymatic resolution products {acetate of (1S,4aS,8aS)-1,2,3, 4,4a,5,6,7,8,8a-decahydro-5,5,8a-trimethyl-2-oxo-trans-naphthalene-1-methanol-2- ethylene acetal} (8aS)-5 (>99% ee)] and [(1R,4aR,8aR)-1,2,3,4,4a,5,6,7,8,8a- decahydro-5,5,8a-trimethyl-2-oxo-trans-naphthalene-1-methanol-2-ethylene acetal (8aR)-4 (98% ee) were converted to (+)-α-polypodatetraene (1) and methyl (5R,10R,13R)-labda-8-en-15-oate (2), respectively. For the synthesis of (5R,10R,13R)-2, chiral isoprene congener (3S)-26 corresponding to the right part of 2 was synthesized based on the lipase-assisted resolution of (±)-2-methyl-3- (p-methoxyphenyl)propanol (17).