6482-34-4

Basic information

• Product Name: Diisopropyl carbonate
• Synonyms: DIPC;DIISOPROPYL CARBONATE;Dissopropyl carbonate;Bis-2-propyl carbonate;Carbonic acid bis(1-methylethyl) ester;Carbonic acid diisopropyl ester;Diisopropyl Carbonate (Stabilized with CalciuM Carbonate)
• CAS NO: 6482-34-4
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 146.18
• Mol File: 6482-34-4.mol
• Article Data: 30

Chemical Properties

• Melting Point: <25 °C
• Boiling Point: 147 °C
• Flash Point: 53 °C
• Appearance: /
• Density: 0.945
• Vapor Pressure: 1.39E-07mmHg at 25°C
• Refractive Index: 1.3932
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate
• CAS DataBase Reference: Diisopropyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: Diisopropyl carbonate(6482-34-4)
• EPA Substance Registry System: Diisopropyl carbonate(6482-34-4)

Safety Data

• Hazardous Substances Data: 6482-34-4(Hazardous Substances Data)

Usage

Description

Diisopropyl carbonate is an organic compound that serves as a valuable intermediate in the synthesis of various pharmaceuticals and chemicals. It is characterized by its ability to facilitate the creation of complex molecules and its potential applications in the medical field.

Uses

Used in Pharmaceutical Synthesis:
Diisopropyl carbonate is used as a synthetic intermediate for the production of Huperizine A (H826000), a reversible alkaloid inhibitor of AChE. Diisopropyl carbonate has the potential to serve as a therapeutic agent for Alzheimer's disease, as it demonstrates the ability to cross the blood-brain barrier and reduce cell death induced by glutamate in primary cultures derived from various regions of the embryonic rat brain.
Used in Alzheimer's Disease Treatment:
In the field of neurology, Diisopropyl carbonate plays a crucial role as a component in the synthesis of Huperizine A, which is being investigated for its potential to treat Alzheimer's disease. Diisopropyl carbonate's ability to inhibit AChE and cross the blood-brain barrier makes it a promising candidate for further research and development in this area.

InChI:InChI=1/C20H26O3/c1-15-6-11-19(18(14-15)20(2,3)4)23-13-12-22-17-9-7-16(21-5)8-10-17/h6-11,14H,12-13H2,1-5H3

Upstream product

• 24425-00-1 diisopropyl pyrocarbonate 
• 201230-82-2 carbon monoxide 
• 683-60-3 sodium isopropylate 
• 108-23-6 isopropyl chloroformate 
• 67-63-0 isopropyl alcohol 
• 75-44-5 phosgene 
• 24425-18-1 isopropyl N,N-difluorocarbamate 
• 4447-60-3 Triisopropoxymethan 
• 75-15-0 carbon disulfide 
• 56-23-5 tetrachloromethane 
• 463-71-8 thiophosgene 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 584-08-7 potassium carbonate 
• 75-26-3 isopropyl bromide 

Downstream Products

• 89145-28-8 1-methyl-4,5-dihydro-5-(2-fluorophenyl)-2-isopropoxycarbonylaminoimidazole 
• 89145-32-4 1-methyl-4,5-dihydro-5-(2-chlorophenyl)-2-isopropoxycarbonylaminoimidazole 
• 156783-96-9 ethyl 2,2,2-trifluoroethyl carbonate 
• 156783-98-1 methyl (2,2,3,3-tetrafluoropropyl) carbonate 
• 156783-95-8 2,2,2-trifluoroethyl methyl carbonate 
• 943-57-7 4-isopropyl phenyl carbonate 
• 67-63-0 isopropyl alcohol 
• 72727-72-1 (Z)-2-(hex-3-en-1-yloxy)tetrahydro-2H-pyran 
• 1189537-08-3 (E)-iso-propyl 2-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-pent-2-enoate 
• 1189537-07-2 (E)-iso-propyl 2-ethyl-5-(tetrahydro-2H-pyran-2-yloxy)-pent-2-enoate 
• 26011-68-7 methyl N-(2-phenylethyl)carbamate 
• 63982-24-1 isopropyl N-(2-phenylethyl)carbamate 
• 103897-19-4 3-benzyltetrahydro-2H-1,3-oxazin-2-one 
• 2453-03-4 trimethylene carbonate 

Relevant articles and documents

Uranyl(VI) Triflate as Catalyst for the Meerwein-Ponndorf-Verley Reaction

Catalytic transformation of oxygenated compounds is challenging in f-element chemistry due to the high oxophilicity of the f-block metals. We report here the first Meerwein-Ponndorf-Verley (MPV) reduction of carbonyl substrates with uranium-based catalysts, in particular from a series of uranyl(VI) compounds where [UO2(OTf)2] (1) displays the greatest efficiency (OTf = trifluoromethanesulfonate). [UO2(OTf)2] reduces a series of aromatic and aliphatic aldehydes and ketones into their corresponding alcohols with moderate to excellent yields, using iPrOH as a solvent and a reductant. The reaction proceeds under mild conditions (80 °C) with an optimized catalytic charge of 2.3 mol % and KOiPr as a cocatalyst. The reduction of aldehydes (1-10 h) is faster than that of ketones (>15 h). NMR investigations clearly evidence the formation of hemiacetal intermediates with aldehydes, while they are not formed with ketones.

METHOD FOR PRODUCING CARBONIC ESTER

To achieve a method for producing a carbonic ester at a high yield by a simple process while suppressing formation of by-products, for example, a method for producing an aliphatic carbonic ester. The above problem is solved by a method for producing a carbonic ester, the method including a carbonic ester formation reaction in which an alcohol and carbon dioxide are reacted in the presence of an aromatic nitrile compound and a catalyst, wherein the water content in the alcohol used in the carbonic ester formation reaction is 0.10% by mass or less.

Transfer hydrogenation of cyclic carbonates and polycarbonate to methanol and diols by iron pincer catalysts

Herein, we report the first example on the use of an earth-abundant metal complex as the catalyst for the transfer hydrogenation of cyclic carbonates to methanol and diols. The advantage of this method is the use of isopropanol as the hydrogen source, thus avoiding the handling of flammable hydrogen under high pressure. The reaction offers an indirect route for the reduction of CO2 to methanol. In addition, poly(propylene carbonate) was converted to methanol and propylene glycol. This methodology can be considered as an attractive opportunity for the chemical recycling of polycarbonates.