67899-59-6

Basic information

• Product Name: 2,3-diphenylpyrido[3,4-b]pyrazine
• Synonyms: 2,3-Diphenylpyrido[3,4-b]pyrazine; pyrido[3,4-b]pyrazine, 2,3-diphenyl-
• CAS NO: 67899-59-6
• Molecular Formula: C₁₉H₁₃N₃
• Molecular Weight: 283.3266
• Mol File: 67899-59-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 434.6°C at 760 mmHg
• Flash Point: 192.1°C
• Density: 1.211g/cm³
• Vapor Pressure: 2.38E-07mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 2,3-diphenylpyrido[3,4-b]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-diphenylpyrido[3,4-b]pyrazine(67899-59-6)
• EPA Substance Registry System: 2,3-diphenylpyrido[3,4-b]pyrazine(67899-59-6)

Safety Data

• Hazardous Substances Data: 67899-59-6(Hazardous Substances Data)

Usage

General Description

2,3-diphenylpyrido[3,4-b]pyrazine is a chemical compound with a fused pyridine and pyrazine ring system. It is a polycyclic aromatic hydrocarbon with two phenyl groups attached to the pyrido[3,4-b]pyrazine ring. 2,3-diphenylpyrido[3,4-b]pyrazine is used in the pharmaceutical industry for the development of new drugs due to its potential biological activities. It is also a common building block in organic synthesis, particularly for the construction of complex heterocyclic compounds. Additionally, 2,3-diphenylpyrido[3,4-b]pyrazine has shown potential as a fluorescent probe for the detection of certain biological molecules and as a material for organic electronic devices. However, it is important to handle this chemical with care due to its potential health and environmental hazards.

Upstream product

• 54-96-6 3,4-diaminopyridine 
• 134-81-6 benzil 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 5088-12-0 (E)-2-bromo-1,2-diphenylethenyl acetate 
• 492-70-6 1,2-diphenyl-1,2-ethanediol 
• 1681-37-4 4-amino-3-nitropyridine 
• 52340-78-0 (R,R)-hydroxybenzoin 

Downstream Products

• 75960-40-6 2,3-Diphenyl-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazine 
• 67899-60-9 cis-1,2,3,4-tetrahydro-2,3-diphenylpyrido<3,4-b>pyrazine 
• 159300-45-5 2,3-diphenyl-6-ethoxycarbonyl-5-cyano-5,6-dihydropyrido<3,4-b>pyrazine 
• 159300-44-4 2,3-diphenyl-6-benzoyl-5-cyano-5,6-dihydropyrido<3,4-b>pyrazine 
• 159300-46-6 2,3-diphenyl-6-(o-chloromethyl)-benzoyl-5-cyano-5,6-dihydropyrido<3,4-b>pyrazine 
• 159300-50-2 5-Cyano-5-methyl-2,3-diphenyl-5H-pyrido[3,4-b]pyrazine-6-carboxylic acid ethyl ester 
• 159300-51-3 2,3-diphenyl-6-carboethoxy-5-cyano-5-benzyl-5,6-dihydropyrido<3,4-b>pyrazine 
• 1305317-09-2 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)benzophenone imine 
• 788821-74-9 8-amino-2,3-diphenylpyrido[3,4-b]pyrazine 
• 1305317-14-9 N-(3-bromophenyl)-2,3-diphenylpyrido[3,4-b]pyrazin-8-amine 
• 1305317-15-0 N-(3-chloro-4-fluorophenyl)-2,3-diphenylpyrido[3,4-b]pyrazin-8-amine 
• 1305317-16-1 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylurea 
• 1305317-17-2 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea 
• 1305317-18-3 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-(3-methoxyphenyl)urea 

Relevant articles and documents

Iron-catalyzed one-pot synthesis of quinoxalines: Transfer hydrogenative condensation of 2-nitroanilines with vicinal diols

Here, we report iron-catalyzed one-pot synthesis of quinoxalines via transfer hydrogenative condensation of 2-nitroanilines with vicinal diols. The tricarbonyl (η4-cyclopentadienone) iron complex, which is well known as the Kn?lker complex, catalyzed the oxidation of alcohols and the reduction of nitroarenes, and the corresponding carbonyl and 1,2-diaminobenzene intermediates were generated in situ. Trimethylamine N-oxide was used to activate the iron complex. Various unsymmetrical and symmetrical vicinal diols were applied for transfer hydrogenation, resulting in quinoxaline derivatives in 49-98% yields. A plausible mechanism was proposed based on a series of control experiments. The major advantages of this protocol are that no external redox reagents or additional base is needed and that water is liberated as the sole byproduct. This journal is

Ionic liquid functionalized cellulose as an efficient heterogeneous catalyst for the facile and green synthesis of benzoxazine, pyrazine and quinoxaline derivatives in aqueous media

Immobilization of acidic ionic liquid, 1-methyl-3-(3-trimethoxysilylpropyl) imidazolium hydrogen sulfate on cellulose (Cell-[pmim]HSO4) as an efficient heterogenous catalyst for the simple and environmentally benign synthesis of benzoxazine, pyrazine and quinoxaline derivatives in aqueous media at room temperature is described. The catalyst was characterized by FTIR spectroscopy and X-ray diffraction pattern. This method provides several advantages such as mild reaction conditions, environmentally friendly catalyst, good to excellent yields and simple work-up procedure.

Synthetic method of quinoxaline heterocyclic compound

The invention provides a synthetic method of a quinoxaline heterocyclic compound. A quinoxaline heterocyclic derivative is prepared through one step by carrying out oxidation and cyclic condensation reaction on benzoin and ortho-diamine under the catalysis of a non-transition metal catalyst. According to the method, low-price and easily-available benzoin is used as a raw material, a water-soluble non-transition metal is used as a catalyst and convenient, economical and safe air is used as a direct oxidant to synthesize a target heterocyclic compound through one step at room temperature or a temperature slightly higher than the room temperature; the reaction condition is simple and mild; and inert gas protection is not needed as the synthesis is carried out in the air. The method is easy to operate, the only byproduct is water, the product is simple and easy to separate and purify, the yield is high, and the reaction condition requirement is relatively low, so that the method is wide in application range and has good research and industrial application prospects.