70263-43-3

Basic information

• Product Name: alpha-(4-bromophenyl)-alpha-vinylpyridine-3-methanol
• Synonyms: alpha-(4-bromophenyl)-alpha-vinylpyridine-3-methanol;α-(4-Bromophenyl)-α-ethenyl-3-pyridinemethanol
• CAS NO: 70263-43-3
• Molecular Formula: C₁₄H₁₂BrNO
• Molecular Weight: 290.15518
• EINECS: 274-519-8
• Mol File: 70263-43-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: alpha-(4-bromophenyl)-alpha-vinylpyridine-3-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-(4-bromophenyl)-alpha-vinylpyridine-3-methanol(70263-43-3)
• EPA Substance Registry System: alpha-(4-bromophenyl)-alpha-vinylpyridine-3-methanol(70263-43-3)

Safety Data

• Hazardous Substances Data: 70263-43-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 3479, 1981 DOI: 10.1021/jo00330a019

Upstream product

• 593-60-2 Vinyl bromide 
• 14548-45-9 (4-bromophenyl)-pyridin-3-yl-methanone 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 108-86-1 bromobenzene 
• 1826-67-1 vinyl magnesium bromide 
• 3536-96-7 vinylmagnesium chloride 

Downstream Products

• 77744-18-4 Acetic acid 1-(4-bromo-phenyl)-1-pyridin-3-yl-allyl ester 
• 91671-06-6 (E)-3-(4-bromophenyl)-3-(3-pyridinyl)prop-2-en-1-ol 
• 77470-73-6 (Z)-3-(4-bromophenyl)-3-(3-pyridinyl)prop-2-en-1-ol 
• 70263-44-4 (Z)-3-(4-bromophenyl)-3-(3-pyridyl) allyl chloride 
• 60324-58-5 A 31119 
• 77470-68-9 (Z)-3-(4-bromophenyl)-3-(3-pyridyl)-2-propenal 
• 60324-67-6 (Z)-3-(4-bromophenyl)-3-(3-pyridyl)allylamine 
• 82103-83-1 (E)-1-(4-bromophenyl)-3-pthalimido-1-(3-pyridyl)propene 
• 82103-82-0 (Z)-1-(4-bromophenyl)-3-pthalimido-1-(3-pyridyl)propene 
• 58574-55-3 (Z)-1-(3-Pyridyl)-1-phenyl-3-dimethylamino-propen 
• 56775-88-3 Zimelidine 
• 79567-79-6 (Z)-3-(4-methylhenyl)-N,N-dimethyl-3-(3-pyridyl)allylamine 
• 79362-30-4 I-ZIM 
• 79567-83-2 (Z)-3-[4-(methylthio)phenyl]-N,N-dimethyl-3-(3-pyridyl)allylamine 

Relevant articles and documents

Synthesis of 3-Aryl-3-pyridylallylamines Related to Zimelidine via Palladium-Catalyzed Amination

Reaction of aryl pyridyl ketones 1 with vinylmagnesium bromide followed by acetylation of the products 2 with acetic anhydride/Et3N and with 4-(dimethylamino)pyridine (DMAP) as a catalyst gave acetates 3 in high yields.Treatment of acetates 3 with dimethylamine in the presence of a palladium catalyst produced a mixture of E and Z isomers of 3-aryl-3-pyridylallylamines 4.

Novel intermediate for preparation of therapeutically active compounds

A novel compound of the formula STR1 useful in the preparation of therapeutically active compounds, especially compounds useful as antidepressive agents; a process for preparation of said compound and a process for preparing therapeutically active compounds employing said compound as an intermediate.