711012-12-3

Basic information

• Product Name: 5-bromo-2-methoxymethoxy-benzoic acid methyl ester
• Synonyms: 5-bromo-2-methoxymethoxy-benzoic acid methyl ester
• CAS NO: 711012-12-3
• Molecular Weight: 275.099
• Mol File: 711012-12-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-methoxymethoxy-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-methoxymethoxy-benzoic acid methyl ester(711012-12-3)
• EPA Substance Registry System: 5-bromo-2-methoxymethoxy-benzoic acid methyl ester(711012-12-3)

Safety Data

• Hazardous Substances Data: 711012-12-3(Hazardous Substances Data)

Upstream product

• 4068-76-2 5-bromo-2-hydroxy-benzoic acid methyl ester 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 35354-74-6 Honokiol 
• 219565-74-9 3'-(2-propenyl)-5-propyl-(1,1'-biphenyl)-2,4'-diol 
• 711012-10-1 2-methoxymethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester 

Relevant articles and documents

Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan

Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki-Miyaura coupling reaction as a key step. Additionally, the structure-activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4′-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol.

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