7210-73-3

Basic information

• Product Name: 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER
• Synonyms: 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER;ethyl 4-Methylthiazole-2-carboxylate;4-Methyl-2-thiazolecarboxylic acid ethyl ester;Ethyl 4-methyl-1,3-thiazole-2-carboxylate;2-(Ethoxycarbonyl)-4-methyl-1,3-thiazole;2-Thiazolecarboxylic acid, 4-methyl-, ethyl ester
• CAS NO: 7210-73-3
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 171.22
• Product Categories: Heterocycles series;API intermediates
• Mol File: 7210-73-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 248.7 °C at 760 mmHg
• Flash Point: 104.2 °C
• Appearance: /
• Density: 1.198 g/cm³
• Storage Temp.: 2-8°C
• PKA: 0.85±0.10(Predicted)
• CAS DataBase Reference: 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER(7210-73-3)
• EPA Substance Registry System: 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER(7210-73-3)

Safety Data

• Hazardous Substances Data: 7210-73-3(Hazardous Substances Data)

Usage

General Description

4-Methylthiazole-2-carboxylic Acid Ethylester is a chemical compound predominantly used in the pharmaceutical industry. It belongs to the organic compound class known as aryl thioethers, which are aromatic compounds containing a sulfur atom linked to an alkyl or aryl group. It's chemical structure is composed of a thiazole ring (a heterocyclic compound consisting of one sulfur atom, one nitrogen atom, and three carbon atoms), with a methyl group and a carboxylic acid ethyl ester group attached. The exact uses, toxicity, and safety measures for this chemical can vary and should always be supervised by a professional in a controlled environment.

Upstream product

• 16982-21-1 ethyl 2-amino-2-thioxoacetate 
• 78-95-5 chloroacetone 
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Downstream Products

• 14542-16-6 4-methyl-1,3-thiazole-2-carboxylic acid 
• 100516-76-5 4-methyl-1,3-thiazole-2-carbohydrazide 
• 16914-23-1 2-Ethoxycarbonyl-3,4-dimethyl-thiazolium-(2,4-dinitro-benzolsulfonat) 
• 16914-25-3 2-ethoxycarbonyl-3,4-dimethyl-thiazolium; toluene-4-sulfonate 
• 78502-74-6 4-Brommethyl-2-thiazolcarbonsaeure-ethylester 
• 78502-75-7 4-Dibrommethyl-2-thiazolcarbonsaeure-ethylester 
• 78502-76-8 4-Tribrommethyl-2-thiazolcarbonsaeure-ethylester 
• 13750-63-5 (4-methylthiazol-2-yl)-methanol 
• 883-34-1 3-methyl-5-phenylimidazo<5,1-b>thiazole 
• 14542-15-5 methyl 4-methyl-1,3-thiazole-2-carboxylate 
• 13750-68-0 4-methyl-thiazole-2-carbaldehyde 
• 103989-44-2 N-benzenesulfonyl-N'-(4-methyl-thiazole-2-carbonyl)-hydrazine 
• 79247-80-6 ethyl 5-bromo-4-methylthiazole-2-carboxylate 
• 1429560-37-1 2-(7-(4-methoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-4-methylthiazole 

Relevant articles and documents

Relationship between mechanochromic behavior and crystal structures in donor-π-acceptor compounds consisted of aromatic rings with ester moiety as an acceptor

We investigated the mechanochromic behavior of donor-π-acceptor compounds which consisted of diphenylaminophenylacetylene as a donor-π moiety and (hetero)aromatic ring bearing ester as an acceptor. The compounds with dicyanobenzoic ester gave the bathochr

5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6 R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

An Infrared Study of Rotational Isomerism in Thiazole-2-carboxylates

A series of alkyl thiazole-2-carboxylates containing a range of substituents at the 4- and 5-positions has been prepared.Solutions of these esters (mostly new compounds) show well resolved doublets in the i.r.C=O region which arise from rotational isomers.The higher wavenumber components are assigned to the more polar carbonyl O,S-anti-s-trans-rotamers and the lower wavenumber components to the carbonyl O,S-syn-s-trans-forms.Small, but systematic, differences between the methyl esters are noted.