72669-49-9

Basic information

• Product Name: L-Valine tert.butyl amide
• Synonyms: L-Valine tert.butyl amide;(S)-2-amino-N-tert-butyl-3-methylbutanamide;(2S)-2-amino-N-tert-butyl-3-methylbutanamide
• CAS NO: 72669-49-9
• Molecular Formula: C₉H₂₀N₂O
• Molecular Weight: 172.2679
• Mol File: 72669-49-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-Valine tert.butyl amide(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine tert.butyl amide(72669-49-9)
• EPA Substance Registry System: L-Valine tert.butyl amide(72669-49-9)

Safety Data

• Hazardous Substances Data: 72669-49-9(Hazardous Substances Data)

Usage

General Description

L-Valine tert.butyl amide is a chemical compound that is derived from the amino acid L-Valine. It is often used in the field of organic synthesis and pharmaceutical research as a reagent and building block for creating various compounds and drugs. L-Valine tert.butyl amide is also commonly used as a protecting group for the amino group in peptide synthesis, helping to prevent unwanted reactions and side products. Additionally, it is known for its ability to enhance the stability and solubility of certain compounds, making it a valuable tool in the development of new pharmaceuticals and other chemical substances.

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 61274-17-7 N-carbobenzoxy-L-valyl-tert-butylamide 
• 86154-20-3 (S)-tert-butyl 1-(tert-butylamino)-3-methyl-1-oxobutan-2-ylcarbamate 
• 13734-41-3 t-Boc-L-valine 
• 70421-65-7 L-valine tert-butylamide hydrochloride 
• 72-18-4 L-valine 
• 5511-73-9 N-phthalimide l-valinyl chloride 
• 178421-57-3 (S)-N-tert-Butyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyramide 
• 6306-54-3 N-phthaloyl L-valine 

Downstream Products

• 161510-58-3 SDZ 282314 
• 890022-49-8 {(R)-1-Benzyl-3-[(S)-2-((S)-1-tert-butylcarbamoyl-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-1-[1,3]dithiolan-2-yl-propyl}-carbamic acid allyl ester 
• 1375257-36-5 (S)-1-tert-butyl-3-[(R)-3-hydroxy-3-phenylpropanoyl]-4-isopropylimidazolidin-2-one 

Relevant articles and documents

Electrostatic repulsion and hydrogen-bonding interactions in a simple N-aryl-L-valinamide organocatalyst control the stereoselectivity in asymmetric aldol reactions

A novel stereocontrol method for asymmetric aldol reactions of aldehydes with ketones is described. The stereoselectivity of the products is controlled by the electrostatic repulsion and hydrogen-bonding interactions of an N-aryl-L-valinamide catalyst. Th

Chiral calcium catalysts for asymmetric hydroamination/cyclisation

Calcium complexes supported by chiral 1,2-diamines have been shown to be efficient catalysts for the asymmetric hydroamination of amino-olefin substrates; the calcium complexes [Ca(NNR){N(SiMe3) 2}(THF)] (R = tBu, iPr, Ph, 4-C 6H4F) give enantioselectivities of up to 26% which marks a significant increase based upon literature precedence. The structure of [Ca(NNPh){N(SiMe3)2}(py)] has been computed with density functional methods.

Synthesis of an enantiomerically pure resorcinarene with pendant L-valine residues and its attachment to a polysiloxane (Chirasil-Calix)

The synthesis of a new enantiomerically pure resorcinarene by reaction of all resorcinic groups with N-bromoacetyl-L-valine-tert-butyl-amide is described. The chiral macrocyclic product was chemically bonded to a poly(hydro)dimethylsiloxane by hydrosilylation using a platinum catalyst. The resulting chiral polysiloxane Chirasil-Calix can be used as chiral stationary phase (CSP) in capillary gas chromatography.