7460-55-1Relevant articles and documents
Capturing Intermediates in the Reaction Catalyzed by NosN, a Class C Radical S-Adenosylmethionine Methylase Involved in the Biosynthesis of the Nosiheptide Side-Ring System
Wang, Bo,Lamattina, Joseph W.,Marshall, Savannah L.,Booker, Squire J.
supporting information, (2019/04/17)
Nosiheptide is a ribosomally synthesized and post-translationally modified thiopeptide natural product that possesses antibacterial, anticancer, and immunosuppressive properties. It contains a bicyclic structure composed of a large macrocycle and a unique
Synthesis and anticancer activities of novel 1,4-disubstituted phthalazines
Li, Juan,Zhao, Yan-Fang,Yuan, Xiao-Ye,Xu, Jing-Xiong,Gong, Ping
, p. 574 - 582 (2007/10/03)
A series of novel 1-anilino-4-(arylsulfanylmethyl)phthalazines were designed and synthesized. The structures of all the compounds were confirmed by IR, 1H-NMR, elemental analysis and MS. The analogues 1-(3-chloro-4-fluoroanilino)-4-(3,4-difluorophenylthio-methyl)phthalazine (12) and 1-(4-fluoro-3-trifluoromethylanilino)-4-(3,4-difluorophenyl-thiomethyl) phthalazine (13) showed higher activity than a cisplatin control when tested in vitro against two different cancer cell lines using the microculture tetrazolium method (MTT) method.