7464-17-7

Basic information

• Product Name: 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea
• CAS NO: 7464-17-7
• Molecular Formula: C₈H₉ClN₄S
• Molecular Weight: 228.7019
• Mol File: 7464-17-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 391.6°C at 760 mmHg
• Flash Point: 190.6°C
• Density: 1.48g/cm³
• Vapor Pressure: 2.43E-06mmHg at 25°C
• Refractive Index: 1.688
• CAS DataBase Reference: 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea(7464-17-7)
• EPA Substance Registry System: 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea(7464-17-7)

Safety Data

• Hazardous Substances Data: 7464-17-7(Hazardous Substances Data)

Usage

Description

1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea, also known as chlormidazole, is a chemical compound with potential antimicrobial and antifungal properties. It is a thiourea derivative that contains a chlorophenyl group and a diaminoalkylidene group, making it a promising candidate for pharmaceutical applications.

Uses

Used in Antimicrobial Applications:
1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea is used as an antimicrobial agent for its potential to treat various bacterial and fungal infections. Its chlorophenyl and diaminoalkylidene groups contribute to its effectiveness against a range of pathogens.
Used in Antifungal Applications:
In the medical industry, 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea is used as an antifungal agent, particularly effective against dermatophytes, which are fungi responsible for skin infections.
Used in Acne Treatment:
1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea is also being investigated for its potential use in the treatment of acne due to its antimicrobial properties, which can help combat the bacteria that contribute to the development of acne.
Further research is necessary to fully understand the therapeutic uses and safety profile of 1-(4-chlorophenyl)-3-(diaminomethylidene)thiourea, but its potential applications in various industries make it a compound of interest for future pharmaceutical development.

Upstream product

• 593-84-0 guanidinium thiocyanate 
• 50-01-1 guanidine hydrochloride 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 124-46-9 guanidine hydrogen carbonate 
• 113-00-8 guanidine nitrate 
• 196877-91-5 1-(4-Chloro-phenyl)-3-[(3,5-dimethyl-pyrazol-1-yl)-imino-methyl]-thiourea 

Downstream Products

• 46440-97-5 1-(4-chloro-phenyl)-2-methyl-biguanide 
• 857396-97-5 N-carbamimidoyl-N'-(4-chloro-phenyl)-S-methyl-isothiourea 
• 132533-34-7 N⁵-(4-Chloro-phenyl)-[1,2,4]thiadiazole-3,5-diamine 
• 107401-72-9 [4-amino-2-(4-chlorophenylamino)thiazol-5-yl](4-chlorophenyl)methanone 
• 857010-29-8 1-(4-chloro-phenyl)-6,6,N²-trimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diyldiamine 
• 1154520-35-0 3-(4-acetyl-phenyl)-2-[4-amino-2-(4-chlorophenylamino)-thiazol-5-yl]-3H-quinazolin-4-one 
• 1154520-34-9 2-[4-amino-2-(4-chloro-phenylamino)-thiazol-5-yl]-3-(4-chloro-phenyl)-3H-quinazolin-4-one 

Relevant articles and documents

NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS

The present invention disclosed a novel EGFR inhibitor compound of formula (I), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (I). Wherein, R= -H, 3-CH3, 4-NO2, 4-Cl, 2-CH3, 4-CH3, 4-Br, 4-F R1= -H, -4-OCH3, -4-NO2,-2-NO2, -4-Cl, -2,4,6-CH3, -4-CH3, -2-F,4-Br, -4-CF3, -4-S-CH3, -4-Cl,-3-CF3, -3-S-CH3, -3,5-CF3, -2-S-CH3, -3-CF3,-4-OCF3, -Si-(CH3)3, -Si-(C2H5)3, (CH3)2-Si- C2H5.

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