7515-41-5

Basic information

• Product Name: [(E)-4-Bromo-1-butenyl]benzene
• Synonyms: [(E)-4-Bromo-1-butenyl]benzene
• CAS NO: 7515-41-5
• Molecular Formula: C₁₀H₁₁Br
• Molecular Weight: 0
• Mol File: 7515-41-5.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(E)-4-Bromo-1-butenyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: [(E)-4-Bromo-1-butenyl]benzene(7515-41-5)
• EPA Substance Registry System: [(E)-4-Bromo-1-butenyl]benzene(7515-41-5)

Safety Data

• Hazardous Substances Data: 7515-41-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 2566, 1980 DOI: 10.1021/jo01301a003

Upstream product

• 1007-03-0 1-phenyl-1-cyclopropylmethanol 
• 770-36-5 4-phenylbuta-3-en-1-ol 
• 100-52-7 benzaldehyde 
• 5162-44-7 1-bromo-4-butene 
• 108-90-7 chlorobenzene 
• 10229-11-5 4-phenyl-but-3-yn-1-ol 
• 937-58-6 (3E)-4-phenyl-3-buten-1-ol 
• 79135-06-1 (Cyclopropylphenylmethoxy)magnesium bromide 
• 23719-80-4 cyclopropylmagnesium bromide 
• 3481-02-5 cyclopropyl phenyl ketone 
• 7515-46-0 (E)-(4-chlorobut-1-en-1-yl)benzene 
• 93652-37-0 4-phenyl-3-butenyl para-toluenesulfonate 
• 7515-38-0 (E)-4-phenylbut-3-en-1-amine 
• 4333-56-6 cyclopropyl bromide 

Downstream Products

• 57238-66-1 (E)-7-phenylhept-6-en-2-one 
• 147429-90-1 1-Methyl-4-((E)-4-phenyl-but-3-enyl)-piperazine 
• 136824-29-8 9-phenyl-1,3(E),8(E)-nonatriene 
• 133627-65-3 3-carbomethoxy-2-methoxy-3-<(E)-4'-phenyl-3'-butenyl>-1,4-cyclohexadiene 
• 824-90-8 1-phenylbut-1-ene 
• 98977-59-4 (E)-N-methyl-N-(4-phenyl-3-butenyl)naphthalenemethanamine 
• 136824-30-1 2-methyl-9-phenyl-1,3(E),8(E)-nonatriene 
• 136824-27-6 5-(4-phenyl-trans-3-butenyl)cyclohexa-1,3-diene 
• 74592-04-4 (E)-2-(4-phenylbut-3-en-1-yl)isoindoline-1,3-dione 
• 634921-79-2 (E)-9-phenyl-8-nonene-2,4-dione 
• 33599-88-1 (E)-6-phenylhex-5-en-2-one 
• 575451-15-9 (6E)-1-diazo-7-phenyl-6-hepten-2-one 
• 200339-73-7 (E)-(4-phenylbut-3-enylsulfonyl)benzene 

Relevant articles and documents

Ring opening of methylenecyclopropanes with halides in liquid sulfur dioxide

Methylenecyclopropanes (MCP) undergo ring opening reactions with group I and II metal halides and ammonium halides in liquid SO2 to afford homoallylic halides, which are versatile reagents in organic synthesis. The developed reaction conditions are compatible with acid-labile substrates such as N-Boc-protected compounds. Liquid SO2 is a polar reaction medium with Lewis acid properties that solubilizes inorganic salts. The unique properties of SO2 were demonstrated by control experiments: 1) upon performing the reactions with the aforementioned salts in conventional solvents, the MCP ring opening was not observed either in the presence of catalytic amounts of H3PO4 (similar pKa to that of H2SO3), or in the absence of H3PO4; 2) a solution of SO2 in THF exhibited similar properties to that of liquid SO2.

Arene Trifunctionalization with Highly Fused Ring Systems through a Domino Aryne Nucleophilic and Diels–Alder Cascade

A convenient and efficient domino aryne process was developed under transition-metal-free conditions to generate a range of tetra- and pentacyclic ring systems. This transformation was realized via a 1,2-benzdiyne through a nucleophilic and Diels–Alder reaction cascade using styrene as the diene moiety. Three new chemical bonds, namely one C?N and two C?C bonds, and two benzofused rings could be constructed concomitantly, which was made possible by distinct chemoselective control at both the 1,2-aryne and 2,3-aryne stages. Moreover, in-depth studies were carried out on the domino aryne precursors and controlling the diastereoselectivity.

Preparation method for p-phenylbutoxybenzoic acid

The invention provides a preparation method for p-phenylbutoxybenzoic acid, belonging to the field of organic synthesis. According to the invention, palladium-based catalytic coupling is adopted, andthe Grignard reaction and the Friedel-Craft reaction are avoided, thereby avoiding the production of blue-green copper ion wastewater and generation of a large amount of acidic wastewater due to usageof aluminum trichloride; the preparation method of the invention is friendly to environment, simple in synthesis route and high in the yield of each step; and halogeno-benzene is used for replacing more expensive phenylmagnesium bromide and used as a starting material, so the preparation cost of p-phenylbutoxybenzoic acid is lowered. The p-phenylbutoxybenzoic acid obtained in the invention has good crystal form, high purity and good solubility. The data of embodiments of the invention show that the total yield of p-phenylbutoxybenzoic acid prepared in the invention is 60% or above, and the HPLC purity of p-phenylbutoxybenzoic acid is 99.9% or above.