75803-23-5

Basic information

• Product Name: methanesulphonic acid,2-(3,4-dimethoxyphenyl)ethyl ester
• Synonyms: methanesulphonic acid,2-(3,4-dimethoxyphenyl)ethyl ester
• CAS NO: 75803-23-5
• Molecular Weight: 260.311
• Mol File: 75803-23-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: methanesulphonic acid,2-(3,4-dimethoxyphenyl)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulphonic acid,2-(3,4-dimethoxyphenyl)ethyl ester(75803-23-5)
• EPA Substance Registry System: methanesulphonic acid,2-(3,4-dimethoxyphenyl)ethyl ester(75803-23-5)

Safety Data

• Hazardous Substances Data: 75803-23-5(Hazardous Substances Data)

Upstream product

• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 6380-23-0 3,4-dimethoxystyrene 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 266674-78-6 1-(3,4-dimethoxyphenyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-7,8-dimethoxy-4-oxo-3H-[1]benzopyrano[3,4-b]pyrrole-4-one 
• 503114-37-2 N-3,4-dimethoxyphenethyl-3',4'-bis-(3,4-dimethoxyphenyl)pyrrole-2-carboxylic acid 
• 3490-06-0 N-methylhomoveratrylamine 
• 49621-56-9 3-(3,4-dimethoxyphenyl)propanenitrile 
• 864528-55-2 4-(2-azidoethyl)-1,2-dimethoxybenzene 
• 1621065-35-7 1-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydropyrimidino[1,2-b][1,2,4]benzothiadiazine 6,6-dioxide 
• 1621065-34-6 1-[2-(3,4-dimethoxyphenyl)ethyl]-2,3-dihydroimidazo[1,2-b][1,2,4]benzothiadiazine 5,5-dioxide 
• 1435951-34-0 C₁₅H₂₁NO₄ 
• 40173-90-8 3,4-dimethoxyphenethyl bromide 
• 64728-23-0 2-(3,4-dimethoxyphenyl)-1-iodoethane 
• 503114-36-1 methyl N-3,4-dimethoxyphenethyl-3',4'-bis-(3,4-dimethoxyphenyl)pyrrole-2-carboxylate 
• 137058-13-0 3-Cyclohexylamino-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-5-methoxy-1,4,5,6-tetrahydro-indol-2-one 

Relevant articles and documents

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

BIOISPIRED PROTEASOME ACTIVATORS WITH ANTIAGEING ACTIVITY

The present invention relates to novel bio-inspired hybrid compounds of formula I which act as proteasome activators and exhibit anti-ageing activity, as well as methods for their synthesis. These hybrid compounds combine the structural features of hydroxytyrosol and the natural antioxidant vitamin E or its bioisosteres in one molecular scaffold. The compounds of formula I, which include structural proteasome activators (activation by stereochemical interaction), can be used in the production of anti-ageing products, such as cosmetic preparations. Additionally, they can be used in conditions and diseases where the proteasome is down-regulated, as well as proteasome-activation control compounds.

Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase

1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) in the non-mevalonate pathway found in most bacteria is a validated anti-infective drug target. Fosmidomycin, a potent DXR inhibitor, is active against Gram-negative bacteria. A coordination chemistry and structure based approach was used to discover a novel, lipophilic DXR inhibitor with an IC50 of 1.4 μM. It exhibited a broad spectrum of activity against Gram-negative and -positive bacteria with minimal inhibition concentrations of 20-100 μM (or 3.7-19 μg/mL).