64728-23-0

Basic information

• Product Name: Benzene, 4-(2-iodoethyl)-1,2-dimethoxy-
• CAS NO: 64728-23-0
• Molecular Formula: C10H13IO2
• Molecular Weight: 292.117
• Mol File: 64728-23-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, 4-(2-iodoethyl)-1,2-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-(2-iodoethyl)-1,2-dimethoxy-(64728-23-0)
• EPA Substance Registry System: Benzene, 4-(2-iodoethyl)-1,2-dimethoxy-(64728-23-0)

Safety Data

• Hazardous Substances Data: 64728-23-0(Hazardous Substances Data)

Upstream product

• 27160-08-3 2-(3,4-dimethoxyphenyl)-ethylchloride 
• 75010-39-8 1-(3,4-dimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethane 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 40173-90-8 3,4-dimethoxyphenethyl bromide 
• 81316-62-3 ethyl 2-(3,4-dimethoxyphenyl)acetoimidate hydrochloride 
• 18066-68-7 ethyl 3,4-dimethoxyphenylacetate 
• 75803-23-5 methanesulphonic acid,2-(3,4-dimethoxyphenyl)ethyl ester 

Downstream Products

• 49621-56-9 3-(3,4-dimethoxyphenyl)propanenitrile 
• 117868-22-1 1-(3,4-dimethoxy-phenethyl)-4-[(3,4-dimethoxy-phenethylcarbamoyl)-methyl]-pyridinium; iodide 
• 101287-60-9 1-(3,4-dimethoxy-phenethyl)-4-methyl-1H-pyridin-2-one 
• 102658-91-3 [1-(3,4-dimethoxy-phenethyl)-[4]piperidyl]-acetic acid ethyl ester 
• 109841-64-7 1-(3,4-dimethoxy-phenethyl)-4-methyl-pyridinium; iodide 
• 1549770-63-9 methyl 6-(4-(3,4-dimethoxyphenyl)-1-methoxy-1-oxobutan-2-yl)-2,3-dimethoxybenzoate 

Relevant articles and documents

Benzo aza compound, preparation method and use thereof

Belonging to the field of pharmaceutical chemistry, the invention relates to a benzoazepine compound, a preparation method and application thereof, in particular to the benzoazepine compound, its preparation method and application in the field of treatment of nervous system diseases, especially application in the field of drug addiction related to dopamine D1 and D3 receptors. The benzoazepine compound and pharmacologically acceptable inorganic or organic salts thereof have a structure shown as formula (I). Results of drug experiments carried out by the invention show that the benzoazepine compound and its pharmacologically acceptable inorganic or organic salts have high antagonistic activity on dopamine D1 and D3, can be used as drug leads for further development of dopamine receptor antagonists with good selectivity and high activity, and can be used as potential drugs for treatment of drug addiction by dopamine D1, D3 receptor antagonists. (formula (I)).

Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase

1-Deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) in the non-mevalonate pathway found in most bacteria is a validated anti-infective drug target. Fosmidomycin, a potent DXR inhibitor, is active against Gram-negative bacteria. A coordination chemistry and structure based approach was used to discover a novel, lipophilic DXR inhibitor with an IC50 of 1.4 μM. It exhibited a broad spectrum of activity against Gram-negative and -positive bacteria with minimal inhibition concentrations of 20-100 μM (or 3.7-19 μg/mL).

Synthesis of alkaloids of Galipea officinalis by alkylation of an α-amino nitrile

A new synthetic approach directed towards the synthesis of naturally occurring 2-alkyl-tetrahydroquinolines is described. The C-C bonds in the α position relative to the nitrogen atom were formed by the reversal of the polarity of the C=N bond of α-amino nitrile 6, which was prepared electrochemically from 1-(phenylethyl)-tetrahydroquinoline. A NaBH 4-mediated reductive decyanation process furnished benzylic amines 16a-d as mixtures of diastereomers (50-60% de). The catalytic hydrogenolysis of these amines was performed in the presence of Pearlman's catalyst to give the tetrahydroquinolines 17a-d in yields ranging from 70% to 95%. Methylation of the free nitrogen atom afforded the title compounds 1-4 in 70-90% yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.