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76066-07-4

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76066-07-4 Usage

Chemical Properties

Off-White Solid

Check Digit Verification of cas no

The CAS Registry Mumber 76066-07-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,0,6 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 76066-07:
(7*7)+(6*6)+(5*0)+(4*6)+(3*6)+(2*0)+(1*7)=134
134 % 10 = 4
So 76066-07-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H5BrN2O3/c1-12-4-2-3-5(9(10)11)8-6(4)7/h2-3H,1H3

76066-07-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Bromo-3-methoxy-6-nitropyridine

1.2 Other means of identification

Product number -
Other names 2-Bromo-3-methoxy-6-nitro-pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76066-07-4 SDS

76066-07-4Synthetic route

2-bromo-3-methoxypyridine
24100-18-3

2-bromo-3-methoxypyridine

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 2 - 55℃;83%
With sulfuric acid; nitric acid at 60℃; for 1h;80%
With sulfuric acid; nitric acid at 50℃; for 4h;80%
3-HYDROXYPYRIDINE
109-00-2

3-HYDROXYPYRIDINE

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 35 percent / Br2, 10percent aq. NaOH / 24 h
2: 1.) NaOCH3 / 1.) MeOH, DMF; 2.) DMF, RT, 1.5 h
3: 80 percent / fuming HNO3, conc. H2SO4 / 1 h / 60 °C
View Scheme
2-bromo-pyridin-3-ol
6602-32-0

2-bromo-pyridin-3-ol

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaOCH3 / 1.) MeOH, DMF; 2.) DMF, RT, 1.5 h
2: 80 percent / fuming HNO3, conc. H2SO4 / 1 h / 60 °C
View Scheme
2-bromo-3-methoxypyridine
24100-18-3

2-bromo-3-methoxypyridine

sulfuric acid
7664-93-9

sulfuric acid

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

Conditions
ConditionsYield
With nitric acid In water
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

2-amino-5-methoxypyridine
10167-97-2

2-amino-5-methoxypyridine

Conditions
ConditionsYield
With hydrazine; palladium 10% on activated carbon In ethanol for 0.75h; Heating / reflux;96%
With hydrazine; palladium 10% on activated carbon In ethanol; water for 0.75h; Heating / reflux;96%
With hydrazine hydrate; palladium on activated charcoal In ethanol for 1.5h; Heating;95%
methanol
67-56-1

methanol

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

2,3-dimethoxy-6-nitropyridine
79491-44-4

2,3-dimethoxy-6-nitropyridine

Conditions
ConditionsYield
With sodium In dimethyl sulfoxide at 30℃; for 2h;81%
zinc(II) cyanide
557-21-1

zinc(II) cyanide

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

3-methoxy-6-nitropicolinonitrile

3-methoxy-6-nitropicolinonitrile

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 4h;78%
sodium methylate
124-41-4

sodium methylate

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

2,3-dimethoxy-6-nitropyridine
79491-44-4

2,3-dimethoxy-6-nitropyridine

Conditions
ConditionsYield
In methanol; dimethyl sulfoxide at 20 - 35℃; for 49.5h;76%
methanol
67-56-1

methanol

sodium methylate
124-41-4

sodium methylate

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

2,3-dimethoxy-6-nitropyridine
79491-44-4

2,3-dimethoxy-6-nitropyridine

Conditions
ConditionsYield
In dimethyl sulfoxide at 20 - 35℃; for 49.5h;76%
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
72824-04-5

2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

2-allyl-3-methoxy-6-nitropyridine
1446792-80-8

2-allyl-3-methoxy-6-nitropyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 66℃; for 20h;75%
With tetrakis(triphenylphosphine) palladium(0); cesium fluoride In tetrahydrofuran at 66℃; for 20h;75%
With tetrakis(triphenylphosphine) palladium(0); cesium fluoride In tetrahydrofuran at 66℃; for 20h;75%
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
126726-62-3

2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

3-methoxy-6-nitro-2-(prop-1-en-2-yl)pyridine
1446792-90-0

3-methoxy-6-nitro-2-(prop-1-en-2-yl)pyridine

Conditions
ConditionsYield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In water; dimethyl amine at 150℃; for 0.333333h; Microwave irradiation; Sealed tube;66%
With tetrakis(triphenylphosphine) palladium(0); cesium fluoride In aq. phosphate buffer; N,N-dimethyl acetamide; water at 150℃; for 0.333333h;66%
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl acetamide; water at 150℃; for 0.333333h; Microwave irradiation; Sealed tube;66%
sodium hydrosulfite (Na2 Ss O4)

sodium hydrosulfite (Na2 Ss O4)

2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

6-bromo-5-methoxypyridin-2-amine
79491-43-3

6-bromo-5-methoxypyridin-2-amine

Conditions
ConditionsYield
With ammonium hydroxide In dichloromethane; water50%
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

6-bromo-5-methoxypyridin-2-amine
79491-43-3

6-bromo-5-methoxypyridin-2-amine

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In ethanol under 760 Torr;46%
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

2-bromo-5-methoxypyridine
105170-27-2

2-bromo-5-methoxypyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

5-methoxy-2-pyridinecarboxaldehyde
22187-96-8

5-methoxy-2-pyridinecarboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: aq. HCl
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

3-(5-Methoxypyridin-2-ylmethyl)-1-methyl-2,3-dihydro-1H-indol
325796-80-3

3-(5-Methoxypyridin-2-ylmethyl)-1-methyl-2,3-dihydro-1H-indol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C
3.2: 40 percent / tetrahydrofuran; hexane / -100 °C
4.1: 85 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 1.5 h / 20 °C / 52504.2 Torr
5.1: 71 percent / NaBH3CN; TFA / acetic acid
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

3-(5-Methoxypyridin-2-ylmethyl)-2,3-dihydroindol-1-carbonsaeuremethylester
325796-82-5

3-(5-Methoxypyridin-2-ylmethyl)-2,3-dihydroindol-1-carbonsaeuremethylester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: NaBH3CN / methanol; acetic acid / 3.5 h
4.2: 82 percent / NaBH3CN; TFA / 16.5 h
5.1: 95 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 45003.6 Torr
6.1: 94 percent / aq. NaHCO3 / diethyl ether / 0 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: 100 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 52504.2 Torr
5.1: 86 percent / TFA; NaBH3CN / acetic acid
6.1: 95 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 45003.6 Torr
7.1: 94 percent / aq. NaHCO3 / diethyl ether / 0 °C
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

5-Methoxy-2-(1-methoxycarbonyl-2,3-dihydro-1H-indol-3-ylmethyl)-1-methylpyridiniumiodid

5-Methoxy-2-(1-methoxycarbonyl-2,3-dihydro-1H-indol-3-ylmethyl)-1-methylpyridiniumiodid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: NaBH3CN / methanol; acetic acid / 3.5 h
4.2: 82 percent / NaBH3CN; TFA / 16.5 h
5.1: 95 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 45003.6 Torr
6.1: 94 percent / aq. NaHCO3 / diethyl ether / 0 °C
7.1: 92 percent / acetone / 120 h
View Scheme
Multi-step reaction with 8 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: 100 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 52504.2 Torr
5.1: 86 percent / TFA; NaBH3CN / acetic acid
6.1: 95 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 45003.6 Torr
7.1: 94 percent / aq. NaHCO3 / diethyl ether / 0 °C
8.1: 92 percent / acetone / 120 h
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

1‐(5‐methoxypyridin‐2‐yl)ethan‐1‐one
325796-84-7

1‐(5‐methoxypyridin‐2‐yl)ethan‐1‐one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C
3.2: tetrahydrofuran; hexane / -100 °C
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

3-(5-Methoxypyridin-2-ylmethyl)-2,3-dihydro-1H-indol
325796-81-4

3-(5-Methoxypyridin-2-ylmethyl)-2,3-dihydro-1H-indol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: NaBH3CN / methanol; acetic acid / 3.5 h
4.2: 82 percent / NaBH3CN; TFA / 16.5 h
5.1: 95 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 45003.6 Torr
View Scheme
Multi-step reaction with 6 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: 100 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 52504.2 Torr
5.1: 86 percent / TFA; NaBH3CN / acetic acid
6.1: 95 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 45003.6 Torr
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

3-(5-Methoxypyridin-2-ylmethyl)-1H-indol

3-(5-Methoxypyridin-2-ylmethyl)-1H-indol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C
3.2: 10 percent / tetrahydrofuran; hexane / -100 °C
4.1: 100 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 52504.2 Torr
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

1-(1H-Indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol
325796-74-5

1-(1H-Indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C
3.2: 10 percent / tetrahydrofuran; hexane / -100 °C
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

1-(1-Methoxymethyl-1H-indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol
325796-73-4

1-(1-Methoxymethyl-1H-indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C
3.2: 40 percent / tetrahydrofuran; hexane / -100 °C
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

1-Methoxymethyl-3-(5-methoxypyridin-2-ylmethyl)-1H-indol
325796-77-8

1-Methoxymethyl-3-(5-methoxypyridin-2-ylmethyl)-1H-indol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C
3.2: 40 percent / tetrahydrofuran; hexane / -100 °C
4.1: 85 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 1.5 h / 20 °C / 52504.2 Torr
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

3-[1-Hydroxy-1-(5-methoxypyridin-2-yl)-methyl]-indol-1-carbonsaeuremethylester

3-[1-Hydroxy-1-(5-methoxypyridin-2-yl)-methyl]-indol-1-carbonsaeuremethylester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / -105 - -100 °C
3.2: 34 percent / tetrahydrofuran; hexane / -100 °C
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

1-Benzyl-3-(5-methoxypyridin-2-ylmethyl)-1H-indol
325796-76-7

1-Benzyl-3-(5-methoxypyridin-2-ylmethyl)-1H-indol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: 100 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 52504.2 Torr
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

1-Benzyl-3-(5-methoxypyridin-2-ylmethyl)-2,3-dihydro-1H-indol
325796-79-0

1-Benzyl-3-(5-methoxypyridin-2-ylmethyl)-2,3-dihydro-1H-indol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: NaBH3CN / methanol; acetic acid / 3.5 h
4.2: 82 percent / NaBH3CN; TFA / 16.5 h
View Scheme
Multi-step reaction with 5 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: 100 percent / H2 / 5 percent Pd/C / ethanol; aq. HCl / 3 h / 20 °C / 52504.2 Torr
5.1: 86 percent / TFA; NaBH3CN / acetic acid
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

1-(1-Benzyl-1H-indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol
325796-72-3

1-(1-Benzyl-1H-indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

C23H24BN3O

C23H24BN3O

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: NaBH3CN / methanol; acetic acid / 3.5 h
4.2: NaBH3CN; TFA / 16.5 h
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

Bis-(1-benzylindol-3-yl)-5-methoxypyridin-2-yl-methan

Bis-(1-benzylindol-3-yl)-5-methoxypyridin-2-yl-methan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 95 percent / N2H4*H2O / 5 percent Pd/C / ethanol / 1.5 h / Heating
2.1: Br2 / aq. HBr / cooling
2.2: 67 percent / aq. NaNO2 / 0.5 h / cooling
3.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -105 - -100 °C
3.2: 60 percent / tetrahydrofuran; hexane / 1.5 h / -100 °C
4.1: aq. HCl
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

5'-Hydroxypiroxicam
77459-78-0

5'-Hydroxypiroxicam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 59 percent / H2, NaOH / 10percent Pd/C / ethanol
2: 59 percent / xylene / 24 h / Heating
3: 30percent HBr, AcOH / 120 h / 100 °C
View Scheme
2-bromo-3-methoxy-6-nitropyridine
76066-07-4

2-bromo-3-methoxy-6-nitropyridine

N-(5'-methoxy-2'-pyridyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
76066-12-1

N-(5'-methoxy-2'-pyridyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 59 percent / H2, NaOH / 10percent Pd/C / ethanol
2: 59 percent / xylene / 24 h / Heating
View Scheme

76066-07-4Relevant articles and documents

1 -(CYCLOPENT-2-EN-1 -YL)-3-(2-HYDROXY-3-(ARYLSULFONYL)PHENYL)UREA DERIVATIVES AS CXCR2 INHIBITORS

-

Page/Page column 131, (2015/12/18)

The invention relates to 1-(3-sulfonylphenyl)-3-(cyclopent-2-en-1-yl)urea derivatives, and their use in treating or preventing diseases and conditions mediated by the CXCR2 receptor. In addition, the invention relates to compositions containing the derivatives and processes for their preparation.

USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME

-

, (2010/08/18)

The invention provides a reagent which can detect amyloid in vitro and in vivo with high sensitivity using a compound which has affinity with amyloid. The reagent for detecting amyloid deposited in a biological tissue comprises the compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represent a carbon or nitrogen, R1 is a group selected from the group consisting of a hydrogen, hydroxyl group, carboxyl group, sulfuric acid group, amino group, nitro group, cyano group, non-radioactive halogen substituent, alkyl substituent with 1 to 4 carbon atoms and alkoxy substituent, with 1 to 4 carbon atoms, and R2 is a radioactive halogen substituent, provided that at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4.

NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID

-

Page/Page column 15; 27, (2010/08/09)

A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R1 is a group selected from the group consisting of a halogen substituent, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and hydroxyl group, R2 is a group selected from the group consisting of a cyano substituent, alkyl substituent with 1 to 4 carbon atoms and halogen substituent, is a group selected from the group consisting of a hydroxyl group, halogen substituent and substituent represented by the following formula: (wherein R4 is a hydrogen, halogen substituent or hydroxyl group, and m is an integer of 1 to 4), provided that a t least one of R1, R2, R3 and R4 represents a radioactive halogen, and a reagent comprising the same.

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