77211-57-5

Basic information

• Product Name: 3-phenyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one
• Synonyms: 3-phenyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one
• CAS NO: 77211-57-5
• Molecular Weight: 366.417
• Mol File: 77211-57-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-phenyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one(77211-57-5)
• EPA Substance Registry System: 3-phenyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one(77211-57-5)

Safety Data

• Hazardous Substances Data: 77211-57-5(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 77211-76-8 1-(carbobenzyloxy)-4-hydroxy-4-(anilinomethyl)piperidine 
• 62-53-3 aniline 
• 77211-75-7 benzyl 1-oxa-6-aza-spiro[2.5]octane-6-carboxylate 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant articles and documents

1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents

Compounds of the formula STR1 wherein R1, R2 and R3 are the same or different and are hydrogen, C1 to C6 alkyl, C6 to C14 carbocyclic aryl or aralkyl of 1 to 6 carbon atoms in the alkyl moiety and 6 to 12 carbon atoms in the carbocyclic aryl moiety and R4 is selected from the group having the formula STR2 where R is C1 to C8 alkyl, C1 to C8 alkoxy, halo, cyano, AlkNHC(O)-- or AlkC(O)NH-- and R' is Alk NHC(O) or Alk C(O)NH where Alk is C1 to C6 alkyl or the group 2-(endobicyclo[3.1.0]hexyl)ethyl. Methods for preparing the compounds are disclosed. The compounds are useful for the treatment of hypertension and cardiac disorders.

Synthesis and antihypertensive activity of a series of 8-substituted 1-oxa-3,8-diazaspiro[4,5]decan-2-ones

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