77211-75-7

Basic information

• Product Name: benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate
• Synonyms: benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate;1-Oxa-6-azaspiro[2.5]octan-6-carboxylic acid benzyl ester;1-Oxa-6-azaspiro[2.5]octan-6-carboxylic acid benzyl ester - X12088
• CAS NO: 77211-75-7
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247
• Mol File: 77211-75-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 389.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.87±0.20(Predicted)
• CAS DataBase Reference: benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate(77211-75-7)
• EPA Substance Registry System: benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate(77211-75-7)

Safety Data

• RIDADR: UN1993
• HazardClass: IRRITANT
• Hazardous Substances Data: 77211-75-7(Hazardous Substances Data)

Usage

General Description

Benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate is a chemical compound with the molecular formula C16H21NO3. It is a derivative of spiro compounds and contains a spiro ring structure. benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical products. It has the potential to exhibit biological activity and can be used as a precursor for the development of new drugs. Additionally, it may have applications in the field of organic chemistry for the synthesis of complex molecules.

Upstream product

• 138163-12-9 benzyl 4-methylene-1-piperidinecarboxylate 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 1774-47-6 trimethylsulfoxonium iodide 
• 16029-98-4 trimethylsilyl iodide 
• 2181-42-2 trimethylsulphonium iodide 

Downstream Products

• 77211-76-8 1-(carbobenzyloxy)-4-hydroxy-4-(anilinomethyl)piperidine 
• 85151-16-2 4-aminomethyl-1-CBZ-piperidin-4-ol 
• 85151-20-8 4-Azidomethyl-4-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 785783-27-9 benzyl 4-[(benzylamino)methyl]-4-hydroxy-1-piperidinecarboxylate 
• 77211-57-5 3-phenyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one 
• 790703-64-9 4-{4-[(5S)-5-(acetylaminomethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 367282-72-2 1-benzyloxycarbonyl-4-hydroxy-4-[N-methyl-N-(ethoxycarbonylmethyl)aminomethyl]piperidine 
• 1025097-53-3 4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 1044574-40-4 phenylmethyl 4-{[(3,4-dichlorophenyl)amino]methyl}-4-hydroxy-1-piperidinecarboxylate 
• 1047655-74-2 benzyl 4-[(cyclohexylamino)methyl]-4-hydroxypiperidine-1-carboxylate 

Relevant articles and documents

Synthesis of Heterospirocycles through Gold-(I) Catalysis: Useful Building Blocks for Medicinal Chemistry

Gold-(I) catalysis was used for the intramolecular cyclization of tertiary alcohols with terminal alkynes to form diverse aza-spirocycles. The reaction was carried out with low catalyst loading under microwave irradiation to give both sulfonylated and acy

Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles

We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization with alkynes, a representative set of heterospirocycles and illustrate reaction compatibility with diverse functional groups. A change in catalytic activity is possible by modifying the solvent, and two original tricyclic spirocycles were synthesized in a tandem reaction.

Synthesis, antibacterial activities, mode of action and acute toxicity studies of new oxazolidinone-fluoroquinolone hybrids

To combat bacterial resistance, a series of new oxazolidinone-fluoroquinolone hybrids have been synthesized and characterized. All synthetic hybrids were preliminarily evaluated for their in vitro antibacterial activities against 6 standard strains and 3 clinical isolates. The majority of hybrids displayed excellent activities against Gram-positive bacteria, but limited activities against Gram-negative bacteria. Hybrids OBP-4 and OBP-5 were found to be the most promising compounds. Further, in vitro antibacterial activities, mode of action and acute toxicity in mice of hybrids OBP-4 and OBP-5 were investigated. Hybrids OBP-4 and OBP-5 exhibited potent activities against Gram-positive bacteria, including drug-resistant strains. Correspondingly, studies on the mode of action of hybrids OBP-4 and OBP-5 indicated a strong inhibitory activity on protein synthesis by binding the active site of 50S subunit, but a weak inhibitory action on DNA synthesis. In addition, LD50 values of hybrids OBP-4 and OBP-5 in the acute oral toxicity were larger than 2000 mg/kg, suggesting a good safety profile.