77211-76-8

Basic information

• Product Name: Benzyl 4-hydroxy-4-[(phenylamino)methyl]-piperidine-1-carboxylate
• Synonyms: Benzyl 4-hydroxy-4-[(phenylamino)methyl]-piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-hydroxy-4-[(phenylamino)methyl]-, phenylmethyl ester
• CAS NO: 77211-76-8
• Molecular Formula: C₂₀H₂₄N₂O₃
• Molecular Weight: 340.41616
• EINECS: 936-634-8
• Mol File: 77211-76-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzyl 4-hydroxy-4-[(phenylamino)methyl]-piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl 4-hydroxy-4-[(phenylamino)methyl]-piperidine-1-carboxylate(77211-76-8)
• EPA Substance Registry System: Benzyl 4-hydroxy-4-[(phenylamino)methyl]-piperidine-1-carboxylate(77211-76-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 77211-76-8(Hazardous Substances Data)

Upstream product

• 77211-75-7 benzyl 1-oxa-6-aza-spiro[2.5]octane-6-carboxylate 
• 62-53-3 aniline 

Downstream Products

• 77211-57-5 3-phenyl-8-(carbobenzyloxy)-1-oxa-3,8-diazaspiro<4.5>decan-2-one 
• 85151-18-4 4-{[(2-Chloro-acetyl)-phenyl-amino]-methyl}-4-hydroxy-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones

Forty-one 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones were prepared for antihypertensive screening in the spontaneously hypertensive rat (SHR). For the 9-(2-indol-3-ylethyl) series, the parent compound 9-(2-indol-3-ylethyl)-1-oxa-4,9-diazaspiro[

8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof

Compounds of the formula STR1 wherein R1, R2 and R3 are the same or different and are hydrogen, C1 to C6 alkyl, C6 to C12 carbocyclic aryl or aralkyl of 1 to 6 carbon atoms in the alkyl moiety and 6 to 12 carbon atoms in the carbocyclic aryl moiety; R4 and R5 are the same or different and are hydrogen or C1 to C6 alkyl; and R6 and R7 are the same or different and are hydrogen, C1 to C6 alkyl or C1 to C6 alkoxy. Methods for preparing these compounds are also disclosed. The compounds are useful as antihypertensives and as diuretics. They also function as antihistamines and as bronchodilating agents and are therefore effective in inhibiting the effects of allergic reactions. They are also of use in the treatment of migraine and in the treatment of vasospastic disorders.