79617-27-9

Basic information

• Product Name: H-ALLO-THR-OME HCL
• Synonyms: ALLO-THREONINE-OME HCL;H-ALLO-THR-OME HCL;L-ALLO-THREONINE METHYL ESTER HYDROCHLORIDE;H-allo-Thr-OMe;(2S,3S)-Methyl 2-aMino-3-hydroxybutanoate hydrochloride
• CAS NO: 79617-27-9
• Molecular Formula: C₅H₁₁NO₃*ClH
• Molecular Weight: 169.61
• Mol File: 79617-27-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 95-97 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: H-ALLO-THR-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-ALLO-THR-OME HCL(79617-27-9)
• EPA Substance Registry System: H-ALLO-THR-OME HCL(79617-27-9)

Safety Data

• Hazardous Substances Data: 79617-27-9(Hazardous Substances Data)

Usage

General Description

H-ALLO-THR-OME HCL is a specialized chemical compound used predominantly in scientific research. It's a derivative of Threonine, one of the 20 standard amino acids, featuring an allo configuration (distinguished by the spatial position of its atoms) and an added methoxy group (-OME). The HCL in its title refers to hydrochloric acid, which means the compound is in its hydrochloride salt form. This format is often used to increase the stability and solubility of bioactive compounds. In the scientific community, this chemical is typically used in the synthesis of peptides, protein study, and other biological applications. Please handle it with care due to its potential corrosiveness because of the HCL component.

Upstream product

• 67-56-1 methanol 
• 72-19-5 DL-threonine 
• 60143-52-4 DL-threonine hydrochloride 
• 72-19-5 rac-allo-threonine 
• 60143-52-4 DL-aThr*HCl 
• 28954-12-3 (2S,3S)-2-amino-3-hydroxybutanoic acid 
• 1487-49-6 3-hydroxybutyric acid methyl ester 
• 72-19-5 D-threonine 
• 72-19-5 L-threonine 

Downstream Products

• 28415-16-9 methyl N-benzoyl (+/-)-threoninate 
• 57224-63-2 Z-DL-Thr-OMe 
• 17554-22-2 CBZ-Phe-Thr-OMe 
• 2458-78-8 methyl N-acetyl-threoninate 
• 57224-63-2 Z-DL-aThr-OMe 
• 28415-16-9 methyl N-benzoyl (+/-)-allo-threoninate 
• 406951-12-0 N-(trans-β-styrenesulfonyl)-L-allo-threonine methyl ester 
• 179094-66-7 (S)-2-((1S,2S)-2-Hydroxy-1-methoxycarbonyl-propylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 515-93-5 (2S,3R)-2-amino-1,3-butanediol 
• 500220-28-0 Boc-L-phenylalanine-L-threonine methyl ester 

Relevant articles and documents

NOVEL COMPOUNDS AND THEIR USE

The present invention provides compounds of the general formula (I) or a pharmaceutically acceptable prodrugs, salts and/or solvates thereof, wherein LHS is selected from the group consisting of LHSa and LHSb And wherein, the asterisk (*) marks the point of attachment; These compounds exhibit antibacterial activity against Gram-negative and Gram-positive bacteria, especially S. aureus, E. coli, K. pneumoniae and A. baumannii. Pharmaceutical compositions containing these compounds, therapeutic uses thereof and methods for manufacturing the same are also provided.

Bicyclic Lactams Derived from Serine or Cysteine and 2-Methylpropanal

Bicyclic lactams may be prepared from serine or cysteine and 2-methylpropanal; the resulting S, N -heterocycles are more stable than the corresponding O, N -heterocycles but both are synthetic intermediates capable of further elaboration.

Synthetic Access to 3-Substituted Pyroglutamic Acids from Tetramate Derivatives of Serine, Threonine, allo-Threonine, and Cysteine

A general route which provides direct access to pyroglutamates from tetramates, making use of Suzuki coupling on an enol mesylate, followed by reduction, is reported. This work permits direct scaffold hopping from tetramate to substituted pyroglutamates. Some compounds in the library showed modest antibacterial activity against Gram-positive bacteria.