802-49-3

Basic information

• Product Name: 1-Propanone, 3-[(4-methoxyphenyl)amino]-1,3-diphenyl-
• CAS NO: 802-49-3
• Molecular Formula: C22H21NO2
• Molecular Weight: 331.414
• Mol File: 802-49-3.mol
• Article Data: 74

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-[(4-methoxyphenyl)amino]-1,3-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-[(4-methoxyphenyl)amino]-1,3-diphenyl-(802-49-3)
• EPA Substance Registry System: 1-Propanone, 3-[(4-methoxyphenyl)amino]-1,3-diphenyl-(802-49-3)

Safety Data

• Hazardous Substances Data: 802-49-3(Hazardous Substances Data)

Usage

Structure

A propane backbone with two phenyl groups and an amino group attached to the third carbon atom, and a methoxy group attached to one of the phenyl groups.

Type of compound

Ketone derivative

Usage

Building block for organic synthesis and pharmaceutical research.

Potential applications

Range of applications due to its structural properties and unique reactivity.

Upstream product

• 13735-81-4 1-styrenyloxytrimethylsilane 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 40339-42-2 4-methoxy-N-[(1Z)-phenylmethylene]aniline 
• 98-86-2 acetophenone 
• 536-90-3 m-Anisidine 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 90-04-0 2-methoxy-phenylamine 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 94-41-7 benzalacetophenone 

Downstream Products

• 614-47-1 1,3-diphenyl-propen-3-one 

Relevant articles and documents

Synthesis of β-Amino Ketones using graphene oxide: a benign carbonaceous acid catalyst for Mannich reaction

Abstract: Simple and easily preparable graphene oxide (GO) is used as a straightforward carbocatalyst for the synthesis of β-amino ketones via a 3-component Mannich reaction under mild condition. The native GO is acting as a carbonaceous solid Br?nsted acid catalyst without any special functionalization, yielding a spectrum of β-amino ketones under metal-free conditions. The present catalytic method offers a benign and simple procedure without any hazardous workup, and chromatographic purification resulted in an excellent yield of β-amino ketones. The catalyst has shown good sustainability up to 6 consecutive catalytic cycles without any significant loss in its activity. The stability of the recovered catalyst is proved by analytical techniques such as FT-IR, PXRD, SEM, and TEM. This mild solid-acid catalyst offers an alternative and sustainable approach to get synthetically essential β-amino ketones under greener conditions. Graphical abstract: [Figure not available: see fulltext.].

An uncommon use of irradiated flavins: Br?nsted acid catalysis

We present that thioacetalization of aldehydes can be induced by blue light irradiation in the presence of a catalytic amount of riboflavin tetraacetate (RFTA) under aerobic conditions. Several control experiments have suggested that the reaction is more

Ionic liquid-immobilized proline(s) organocatalyst-catalyzed one-pot multi-component Mannich reaction under solvent-free condition

A highly efficient clean and simple methodology has been established for the one-pot Mannich reaction using ionic liquid-immobilized proline(s) organocatalyst under solvent-free conditions. The three components comprising substituted acetophenones, substituted aromatic aldehydes and substituted aromatic amines underwent Mannich reactions in the presence of 7?mol% of ionic liquid-immobilized proline(s) organocatalyst to provide β-amino carbonyl compounds in 2–3?h at room temperature with excellent yields. This methodology provides several advantages such as mild reaction conditions, short reaction time, low catalyst loading percentage, multi-component approach, transition metal-free and solvent-free synthesis. The ionic liquid-immobilized proline(s) organocatalyst was recycled and reused five times without a significant loss of its catalytic activity.