82584-73-4

Basic information

• Product Name: Epibromhidrina [Spanish]
• Synonyms: Epibromhidrina [Spanish]
• CAS NO: 82584-73-4
• Molecular Formula: C3H5BrO
• Molecular Weight: 136.9752
• Mol File: 82584-73-4.mol
• Article Data: 29

Chemical Properties

• Melting Point: -40°C
• Boiling Point: 137°C (estimate)
• Appearance: /
• Density: 1.6150
• Refractive Index: 1.4841
• CAS DataBase Reference: Epibromhidrina [Spanish](CAS DataBase Reference)
• NIST Chemistry Reference: Epibromhidrina [Spanish](82584-73-4)
• EPA Substance Registry System: Epibromhidrina [Spanish](82584-73-4)

Safety Data

• Hazardous Substances Data: 82584-73-4(Hazardous Substances Data)

Upstream product

• 96-21-9 1,3-dibromo-2-hydroxypropane 
• 56-81-5 glycerol 
• 106-89-8 epichlorohydrin 
• 96-13-9 2,3-Dibromopropan-1-ol 
• 106-95-6 allyl bromide 
• 6308-13-0 1-acetoxy-2,3-dibromopropane 
• 359-01-3 2-fluorobutane 
• 40152-79-2 1-amino-3-bromopropan-2-ol 
• 83398-54-3 Toluene-4-sulfonic acid (R)-3-bromo-2-hydroxy-propyl ester 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 83165-36-0 (2S)-2,3-dibromopropan-1-ol 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 49847-41-8 3-cyclohexyl-6-hydroxy-6,7-dihydro-5H-tetrazolo[5,1-b][1,3]thiazinium; bromide 
• 72410-28-7 6-hydroxymethyl-4,4-dimethyl-2-phenyl-5,6-dihydro-4H-[1,3,4]oxadiazinium; bromide 
• 34035-39-7 6,7-diphenyl-2H,3H,4H-3-hydroxytetrahydroimidazo[2,1-b][1,3]thiazine 
• 71818-98-9 2-(4-chloro-phenyl)-2-morpholin-4-yl-3-oxiranyl-propionitrile 
• 102104-54-1 2-(4-Methoxy-phenylethynylselanylmethyl)-oxirane 
• 102104-58-5 1,3-Bis-(4-methoxy-phenylethynylselanyl)-propan-2-ol 
• 344866-89-3 4,5-dihydro-1-phenyl-1,4-epoxy-1H,3H <1,4> oxazepino <4,3-a> benzimidazole 
• 119672-64-9 1-phenylthio-3-hydroxycyclobutane 
• 119672-63-8 1-phenylthio-3-trimethylsiloxycyclobutane 
• 119672-66-1 1,5-di(phenylthio)-pentan-3-ol 
• 141860-41-5 (+/-)-4-benzyloxy-3-<(2,3-epoxypropan-1-yl)oxy>benzaldehyde 
• 154910-09-5 1-(Phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one 
• 125830-45-7 (Z)-3-Amino-2,4-bis-((R)-4-phenyl-oxazolidin-3-yl)-but-2-enenitrile 
• 118970-47-1 (1R,2R)-2-Hydroxymethyl-1-((R)-4-phenyl-oxazolidin-3-yl)-cyclopropanecarbonitrile 

Relevant articles and documents

Visible-light assisted of nano Ni/g-C3N4 with efficient photocatalytic activity and stability for selective aerobic C?H activation and epoxidation

A selective, economical, and ecological protocol has been described for the oxidation of methyl arenes and their analogs to the corresponding carbonyl compounds and epoxidation reactions of alkenes with molecular oxygen (O2) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C3N4 exhibited high photocatalytic activity, stability, and selectivity in the C?H activation of methyl arenes, methylene arenes, and epoxidation of various alkenes under visible- light irradiation without the use of an oxidizing agent and under base free conditions.

Thiourea composite feed additive with urease inhibition activity and preparation method thereof

The invention discloses a thiourea composite feed additive with urease inhibition activity and a preparation method thereof, and belongs to the technical field of synthesis of feed additives. The technical scheme is characterized in that the compound structure of the thiourea composite feed additives is shown in the description. Compared with the prior art, the thiourea composite feed additive hasthe following beneficial effects: 1, the non-protein nitrogen group and the nitrogen-containing micromolecule urease inhibitor group can be linked together through the hydrophilic group by the feed additive obtained by the method, meanwhile, functions of supplementing non-protein nitrogen and inhibiting urease are provided; 2, the tandem non-protein nitrogen group and the nitrogen-containing small molecule urease inhibitor group are completed by 2-hydroxy propane through oxygen and imino, which is an excellent hydrophilic group, has good water solubility, has a stable molecular structure in vitro, and can effectively release a non-protein nitrogen group and a nitrogen-containing micromolecule urease inhibitor group in gastric juice; 3, the feed additive has no toxic or side effect; 4, themethod has simple operation and high product yield.

Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents

Toll-like receptor 4 (TLR4) initiates innate immune response to release inflammatory cytokines and has been pathologically linked to variety of inflammatory diseases. Recently, we found that Carvedilol, as the classic anti-heart failure and anti-inflammatory clinic drug, could inhibit the TLR4 signaling in the TLR4 overexpressed cells. Herein, we have designed and synthesized a small library of novel Carvedilol derivatives and investigated their potential inhibitory activity. The results indicate that the most potent compound 8a (SMU-XY3) could effectively inhibited TLR4 protein and the LPS triggered alkaline phosphatase signaling in HEK-Blue hTLR4 cells. It down regulated the nitric oxide (NO) in both RAW264.7 cells and BV-2 microglial cells, in addition to blocking the TNF-α signaling in ex-vivo human peripheral blood mononuclear cells (PBMC). More interestingly, 8a shows higher affinity to hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) over HCN2, which probably indicates the new application of TLR4 inhibitor 8a in heart failure, coronary heart disease, and other inflammatory diseases.