82768-84-1

Basic information

• Product Name: 2-[N-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
• Synonyms: 3-isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-
• CAS NO: 82768-84-1
• Molecular Formula: C₂₅H₃₀N₂O₅
• Molecular Weight: 438.5161
• Mol File: 82768-84-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 662°C at 760 mmHg
• Flash Point: 354.1°C
• Density: 1.217g/cm³
• Vapor Pressure: 2E-18mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 2-[N-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[N-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(82768-84-1)
• EPA Substance Registry System: 2-[N-(1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid(82768-84-1)

Safety Data

• Hazardous Substances Data: 82768-84-1(Hazardous Substances Data)

Usage

Functional Groups

Alanyl group: Contains an amino acid derivative.
Tetrahydroisoquinoline ring: A bicyclic ring system.
Carboxylic acid group: Provides acidity and potential reactivity.
Ethoxy group: An ether functional group (-OCH2CH3).
Ketone group: A carbonyl functional group (C=O).
Phenyl group: An aromatic ring (-C6H5).

Nature

Synthetic compound, not naturally occurring.

Potential Applications

Likely pharmaceutical or research applications due to its complex structure.

Specific Uses

Not specified, but its complex structure suggests potential utility in drug design, organic synthesis, or chemical research.

Properties

Molecular Formula: C26H31NO6
Molecular Weight: Approximately 453.54 g/mol
Structure: Complex and likely exhibits stereochemistry due to multiple chiral centers.
Solubility: May vary depending on specific functional groups and environment.
Stability: Stability under various conditions would need to be assessed experimentally.

Reactivity

Potential reactivity due to multiple functional groups, particularly the carboxylic acid and ketone groups.

Synthesis

Likely requires complex organic synthesis techniques to assemble its intricate structure.

Research Interest

Its complex structure may attract interest from organic chemists, pharmacologists, and researchers exploring novel compounds for various applications.

Upstream product

• 82586-56-9 tert-butyl (S)-2-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 82586-55-8 quinapril hydrochloride 
• 82586-54-7 quinapril benzyl ester 
• 82717-96-2 [1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine 
• 124492-03-1 N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-(S)-alanine-2'-benzothiazolylthio ester 
• 74163-81-8 L-Tic-OH 
• 77497-74-6 (S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, 1,1-dimethylethyl ester 
• 80828-26-8 N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine hydrochloride 
• 877932-98-4 N-(1-ethoxycarbonyl-3-phenylpropyl)-L-alanine 
• 129178-93-4 L-alanine acid chloride 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 82768-85-2 quinaprilate 

Relevant articles and documents

COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING SALT SENSITIVITY OF BLOOD PRESSURE

To characterize the urinary exosome miRNome, microarrays were used to identify the miRNA spectrum present within urinary exosomes from ten individuals that were previously classified for their salt sensitivity status. The present application discloses distinct patterns of selected exosomal miRNA expression that were different between salt-sensitive (SS), salt-resistant (SR), and inverse salt-sensitive (ISS) individuals. These miRNAs can be useful as biomarkers either individually or as panels comprising multiple miRNAs. The present invention provides compositions and methods for identifying, diagnosing, monitoring, and treating subjects with salt sensitivity of blood pressure. The applications discloses panels of miRNAs useful for comparing profiles, and in some cases one or more of the miRNAs in a panel can be used. The miRNAs useful for distinguishing SS and SR or ISS and SR subjects. One or more of the 45 miRNAs can be used. Some of the miRNAs have not been previously reported to be circulating. See those miRNAs with asterisks in FIG. 1 and below. The present invention encompasses the use of one or more of these markers for identifying and diagnosing SR, SS, and ISS subjects.

2′-Benzothiazolylthioesters of N-substituted alpha amino acids: Versatile intermediates for synthesis of ACE inhibitors

ACE inhibitors have been synthesized from novel active esters using simple reaction conditions in high diastereomeric selectivity. The active esters may be obtained from the corresponding carboxylic acids or their acid chlorides.

Process for preparing an angiotensin converting enzyme inhibitor

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