84-86-6

Basic information

• Product Name: Naphthionic acid
• Synonyms: 4-AMINO-1-NAPHTHALENESULPHONICACID;1-Naphthylamine-4-sulfonic acid, Naphthionic acid;4-Amino-1-naphthalenesulfonic acid,98%;Naphthionic Acid 1-Naphthylamine-4-sulfonic Acid;4-Aminonaphthalene-1-sulfonic acid for synthesis;1,4-Naphthionic acid;1,4-naphthionicacid;1-Aminonaphthalene-4-sulfonic acid
• CAS NO: 84-86-6
• Molecular Formula: C₁₀H₉NO₃S
• Molecular Weight: 223.25
• EINECS: 201-567-9
• Product Categories: Intermediates of Dyes and Pigments;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfonic/Sulfinic Acids;Sulfur Compounds
• Mol File: 84-86-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: ≥300 °C(lit.)
• Boiling Point: 220°C (rough estimate)
• Appearance: Slightly greyish to beige powder and granule
• Density: 1.67
• Refractive Index: 1.5250 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: Sparingly soluble in dichloromethane. Soluble in aqueous base.
• PKA: pK1: 2.81 (25°C)
• Water Solubility: 309.9mg/L(20 oC)
• Merck: 14,6403
• BRN: 1971299
• CAS DataBase Reference: Naphthionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Naphthionic acid(84-86-6)
• EPA Substance Registry System: Naphthionic acid(84-86-6)

Safety Data

• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-36/37/39-45-25
• RIDADR: UN 2585 8/PG 3
• WGK Germany: 3
• RTECS: QK1270000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 84-86-6(Hazardous Substances Data)

Usage

Chemical Properties

slightly greyish to beige powder and granules

Uses

Different sources of media describe the Uses of 84-86-6 differently. You can refer to the following data:
1. Intermediate for azo dyes, e.g., Congo red.
2. 4-Amino-1-naphthalenesulfonic acid has potent therapeutic applications. Its sodium salt has been used as non-toxic hemostatic. It is also a metabolite of azo dyes.

General Description

4-Amino-1-naphthalenesulfonic acid is a diazo compound. It is also known as Piria′s acid.

Purification Methods

It crystallises from H2O as needles of the 0.5 hydrate. Salt solutions fluoresce strongly blue. The S-benzylisothiuronium salt has m 195o (from aqueous EtOH). [Beilstein 14 IV 2793.]

InChI:InChI=1/C10H9NO3S/c11-9-5-6-10(15(12,13)14)8-4-2-1-3-7(8)9/h1-6H,11H2,(H,12,13,14)

Upstream product

• 86-57-7 1-Nitronaphthalene 
• 21711-65-9 1-naphthylnitrosobenzene 
• 575-36-0 1-acetamidonaphthalene 
• 162109-20-8 1-bromo-4-naphthalenesulfonic acid 
• 607-30-7 hydroxynaphthylamine 
• 6328-72-9 4-chloro-1-naphthylsulphonic acid 
• 117-55-5 4-aminonaphthalene-1,5-disulfonic acid 
• 134-32-7 1-amino-naphthalene 
• 612-52-2 2-naphthylamine hydrochloride 
• 82-75-7 8-anilino-1-naphthalenesulfonate 
• 915-67-3 amaranth 
• 193887-78-4 citraconimide of 1-naphthylamine 
• 7664-93-9 sulfuric acid 
• 7790-94-5 chlorosulfonic acid 

Downstream Products

• 7355-16-0 4-amino-3-(2-phenyl-1-diazenyl)-1-naphthalenesulfonic acid 
• 188066-01-5 4-amino-3-(4-sulfo-phenylazo)-naphthalene-1-sulfonic acid 
• 571-60-8 1,4-Dihydroxynaphthalene 
• 90-15-3 α-naphthol 
• 84-87-7 1-hydroxy-4-naphthalenesulfonate 
• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 116-63-2 1-amino-2-naphthol-4-sulfonic acid 
• 4684-12-2 1-amino-4-chloronaphthalene 
• 2298-07-9 4-Bromo-1-naphthylamine 
• 20191-76-8 2,4-dibromo-1-naphthylamine 
• 85-74-5 4-amino-1,7-naphthalenedisulphonic acid 
• 85-75-6 4-aminonaphthalene-1,6-disulfonic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 130-15-4 [1,4]naphthoquinone 

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This invention is directed to the acylation of aminosulfonic acids in the solid phase. Two discrete, sequential chemical reactions occur, i.e. (1) the neutralization of the aminosulfonic acid, and (2) the subsequent amine acylation, to produce an improved neutralized acyl-aminosulfonic acid at a reduced cost. Aminosulfonic acids having the general formula HO3 S-A-NH2 are acylated to neutralized acyl-aminosulfonic acids having the general formula RCONH-A-SO3 M, where A is an unsubstituted or substituted aliphatic, aromatic or heteroaromatic group and M is a neutralizing agent moiety. The yield is virtually quantitative.