84839-91-8

Basic information

• Product Name: 3-(2-METHYLPHENYL)PROPIOPHENONE
• Synonyms: 3-(2-METHYLPHENYL)PROPIOPHENONE
• CAS NO: 84839-91-8
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.3
• Mol File: 84839-91-8.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 371°C at 760 mmHg
• Flash Point: 161.2°C
• Appearance: /
• Density: 1.045g/cm³
• Vapor Pressure: 1.07E-05mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 3-(2-METHYLPHENYL)PROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHYLPHENYL)PROPIOPHENONE(84839-91-8)
• EPA Substance Registry System: 3-(2-METHYLPHENYL)PROPIOPHENONE(84839-91-8)

Safety Data

• Hazardous Substances Data: 84839-91-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O/c1-13-7-5-6-8-14(13)11-12-16(17)15-9-3-2-4-10-15/h2-10H,11-12H2,1H3

Upstream product

• 53423-27-1 2-(2-methylphenyl)-1-phenylpropan-1-one 
• 98-88-4 benzoyl chloride 
• 122383-46-4 tert-Butyl α-(methylbenzyl)malonate 
• 108-88-3 toluene 
• 768-03-6 Phenyl vinyl ketone 
• 89-92-9 2-methylbenzyl bromide 
• 16619-28-6 1-phenyl-3-o-methylphenyl-2-propen-1-one 
• 615-37-2 ortho-methylphenyl iodide 
• 37442-45-8 ethyl 2-(hydroxy(phenyl)methyl)propenoate 
• 22966-01-4 2-methyl-trans-chalcone 
• 98-85-1 1-Phenylethanol 
• 89-95-2 2-methyl-benzyl alcohol 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 1436413-25-0 C₂₃H₁₉N 
• 1254977-20-2 C₁₆H₁₄ 

Relevant articles and documents

Electrochemical-Induced Hydrogenation of Electron-Deficient Internal Olefins and Alkynes with CH3OH as Hydrogen Donor

Efficient hydrogenation of electron-deficient internal olefins and alkynes access to saturate ketone with CH3OH as a single hydrogen donor under electrochemical conditions has been successfully developed. This hydrogenation strategy can be used to convert electron-deficient internal olefins and alkynes to saturate ketone under electrochemical conditions with exogenous-reductant and a metal catalyst. Mechanistic studies reveal that radical hydrogenation was involved in this transformation. Notably, various electron-deficient internal olefins and alkynes could be tolerated in such an electrochemical hydrogenation synthetic strategy and can be easily scaled up with good efficiency. (Figure presented.).

Iridium Complexes as Efficient Catalysts for Construction of α-Substituted Ketones via Hydrogen Borrowing of Alcohols in Water

Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes-catalyzed cross-coupling of alcohols via hydrogen borrowing, affording a series of α-alkylated ketones in high yield (86 %–95 %) and chemoselectivities (>99 : 1). This methodology has the advantages of low catalyst loading (0.1 mol%) and environmentally benign water as the solvent. Studies have shown the amount of base has a great impact on chemoselectivities. Meanwhile, deuteration experiments show water plays an important role in accelerating the reduction of the unsaturated ketones intermediates. Remarkably, a gram-scale experiment demonstrates this methodology of iridium-catalyzed cross-coupling of alcohols has potential application in the practical synthesis of α-alkylated ketones.

Sustainable and Selective Alkylation of Deactivated Secondary Alcohols to Ketones by Non-bifunctional Pincer N-heterocyclic Carbene Manganese

A sustainable and green route to access diverse functionalized ketones via dehydrogenative–dehydrative cross-coupling of primary and secondary alcohols is demonstrated. This borrowing hydrogen approach employing a pincer N-heterocyclic carbene Mn complex displays high activity and selectivity. A variety of primary and secondary alcohols are well tolerant and result in satisfactory isolated yields. Mechanistic studies suggest that this reaction proceeds via a direct outer-sphere mechanism and the dehydrogenation of the secondary alcohol substrates plays a vital role in the rate-limiting step.