855473-48-2

Basic information

• Product Name: (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate
• Synonyms: (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate
• CAS NO: 855473-48-2
• Molecular Weight: 516.06
• Mol File: 855473-48-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate(855473-48-2)
• EPA Substance Registry System: (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate(855473-48-2)

Safety Data

• Hazardous Substances Data: 855473-48-2(Hazardous Substances Data)

Usage

Uses

2-[(3R)-3-(Acetylthio)-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl]-Benzoic Acid Methyl Ester is a reagent in the preparation of Montelukast Sodium Salt (M568000) which is a selective leukotriene D4-receptor antagonist. Used as an antiasthmatic.

Upstream product

• 906107-36-6 Methyl [S-(E)]-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-methanesulfonyloxy-propyl] benzoate 
• 507-09-5 tiolacetic acid 
• 10387-40-3 potassium thioacetate 
• 181139-72-0 methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate 

Downstream Products

• 937275-17-7 C₇H₈O₃S*C₃₀H₂₆ClNO₃S 
• 937389-18-9 C₃₀H₂₆ClNO₃S*ClH 
• 855473-51-7 1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester 
• 855473-49-3 C₂₉H₂₈ClNOS 

Relevant articles and documents

Efficient synthesis for the preparation of montelukast

The present invention describes the improved process for the preparation of montelukast acid and its pharmaceutically acceptable salts and esters. The process is cost effective, environment friendly, and easily scale up to commercial level.

PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR

A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: (1) using a compound of formula (11) is provided.