855473-49-3

Basic information

• Product Name: C₂₉H₂₈ClNOS
• Synonyms: C₂₉H₂₈ClNOS
• CAS NO: 855473-49-3
• Molecular Weight: 474.066
• Mol File: 855473-49-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₉H₂₈ClNOS(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₂₈ClNOS(855473-49-3)
• EPA Substance Registry System: C₂₉H₂₈ClNOS(855473-49-3)

Safety Data

• Hazardous Substances Data: 855473-49-3(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 855473-48-2 (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate 
• 937366-40-0 (3R)-{3-[(E)-2-(7-chloro-2-quinolinyl)vinyl]phenyl}-4,5-dihydro-3H-benzo[c]thiepin-1-one 

Downstream Products

• 937275-14-4 C₇H₈O₃S*C₂₉H₂₈ClNOS 
• 855473-51-7 1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester 
• 158966-92-8 montelukast 
• 151767-02-1 Montelukast sodium 

Relevant articles and documents

EFFICIENT SYNTHESIS FOR THE PREPARATION OF MONTELUKAST AND NOVEL CRYSTALLINE FORM OF INTERMEDIATES THEREIN

The present invention describes the improved process for the preparation of montelukast acid (VII) and its pharmaceutically acceptable salts and esters using a novel synthesis step. The process is cost effective, environment friendly, and easily scale up to commercial level and leads to products having high chemical and optical purity. Moreover, the present invention provides a novel crystalline intermediate (IV) that is useful in this process and a method for its production. In a further aspect, the process of the present invention includes a step of removing ketone by-products be derivatization.