855473-51-7

Basic information

• Product Name: Montelukast Methyl Ester
• Synonyms: Montelukast Methyl Ester;Montelukast Acid Methyl Ester
• CAS NO: 855473-51-7
• Molecular Formula: C₃₆H₃₈ClNO₃S
• Molecular Weight: 600.20982
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 855473-51-7.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: Montelukast Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Montelukast Methyl Ester(855473-51-7)
• EPA Substance Registry System: Montelukast Methyl Ester(855473-51-7)

Safety Data

• Hazardous Substances Data: 855473-51-7(Hazardous Substances Data)

Usage

Uses

Montelukast Methyl Ester is an impurity of the antiasthmatic drug Montelukast (M568000).

Upstream product

• 152922-73-1 2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester 
• 807638-71-7 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol 
• 142148-14-9 methyl 1-(acetylthiomethyl)cyclopropylacetic acid 
• 1141487-07-1 2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-diphenylphosphate oxypropyl)phenyl)-2-propanol 
• 920739-17-9 (S)-benzenepropanol α-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(1-hydroxy-1-methyl ethyl)-α-methane sulfonate 
• 855473-50-6 1-bromomethylcyclopropyl acetic acid methyl ester 
• 855473-48-2 (R,E)-methyl 2-(3-(acetylthio)-3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)propyl)benzoate 
• 169954-93-2 2-(2-(3(S)-(3-(2-(7-chloroquinolin-2-yl)ethyl)phenyl)-3-(methanesulfonyl-1-oxy)methylethyl)phenyl)-2-propanol 
• 142569-70-8 (S)-1-{3-[2-(7-chloroquinolin-2-yl)ethylene]-phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]-propan-1-ol 
• 75-16-1 methylmagnesium bromide 
• 855473-49-3 C₂₉H₂₈ClNOS 
• 67-56-1 methanol 
• 1197374-06-3 montelukast 1-methyl-3-phenylpropyl amine salt 
• 918972-54-0 [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-[1-(1-methyl)ethenyl]phenyl]propyl]thio]methyl]cyclopropaneacetic acid 

Downstream Products

• 158966-92-8 montelukast 
• 151767-02-1 Montelukast sodium 
• 577953-88-9 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt 
• 1399184-58-7 (1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid diisobutylamine salt 
• 880769-26-6 1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt 
• 1334676-80-0 [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[(prop-1-en-2-yl)phenyl]propyl]thio]methyl]cyclopropane acetic acid methyl ester 

Relevant articles and documents

Triphosgene and DMAP as Mild Reagents for Chemoselective Dehydration of Tertiary Alcohols

The utility of triphosgene and DMAP as mild reagents for chemoselective dehydration of tertiary alcohols is reported. Performed in dichloromethane at room temperature, this reaction is readily tolerated by a broad scope of substrates, yielding alkenes preferentially with the (E)-geometry. While formation of the Hofmann products is generally favored, a dramatic change in alkene selectivity toward the Zaitzev products is observed when the reaction is carried out in dichloroethane at reflux.

Menglusitena a high yield new method for the synthesis of (by machine translation)

The invention discloses a method for preparing Menglusitena, the method adopts a one-pot synthesis, in order to 2 - (2 - (3 - (2 - (7-chloro-2-quinolyl) vinyl) phenyl) - 3-oxo-propyl) phenyl) propyl alcohol as the starting material, and 1 - (thiomethyl)-c

MONTELUKAST INTERMEDIATE CAMPHORSULFONIC SALT

The present invention is directed to a novel salt of a montelukast intermediate, the process of preparation thereof, the use of such salt in the preparation of sodium montelukast and a process for the preparation of sodium montelukast making use of said salt.