87199-18-6

Basic information

• Product Name: 3-Hydroxyphenylboronic acid
• Synonyms: 3-Hydroxyphenylboronic Acid (contains varying amounts of Anhydride);3-Hydroxyphenylboronic acid,97%;3-Hydroxyphenylboronic acid ,98%;3-Hydroxyphenylboronic acid, May contain varying amounts of anhydride, 97%;m-Hydroxybenzeneboronic acid;3-Hydroxyphenylboronic acid >=95.0%;B-(3-hydroxy-phenyl)boronic acid;3-Hydroxybenzeneboronic Acid 3-Boronophenol
• CAS NO: 87199-18-6
• Molecular Formula: C₆H₇BO₃
• Molecular Weight: 137.93
• Product Categories: Aryl;Organoborons;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids & Esters;Phenyls & Phenyl-Het;Boronic Acids;Boronic Acids and Derivatives;Boronate Ester;Potassium Trifluoroborate;blocks;BoronicAcids;Substituted Boronic Acids;Boronic Acids & Esters;Phenyls & Phenyl-Het;Organic acids;Boronic Acid
• Mol File: 87199-18-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 210-213 °C (dec.)(lit.)
• Boiling Point: 370 °C at 760 mmHg
• Flash Point: 177.6 °C
• Appearance: Pink to gray to tan/Crystalline Powder, Crystals and/or Chunks
• Density: 1.32 g/cm³
• Vapor Pressure: 3.95E-06mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: pK1:8.55;pK2:10.84 (25°C)
• BRN: 3240771
• CAS DataBase Reference: 3-Hydroxyphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxyphenylboronic acid(87199-18-6)
• EPA Substance Registry System: 3-Hydroxyphenylboronic acid(87199-18-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 87199-18-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

Different sources of media describe the Uses of 87199-18-6 differently. You can refer to the following data:
1. suzuki reaction
2. 3-Hydroxyphenylboronic acid (3-HPBA) can be used as a reagent: In Suzuki-Miyaura coupling reactions with aryl halides for the formation of C-C bond in the presence of Pd catalyst.?To synthesize boron/nitrogen-doped polymer nano/microspheres by hydrothermal polymerization with formaldehyde and ammonia.?????? To prepare carbon quantum dots based on 3-HPBA as selective fructose sensor.????? In the development of modified electrodes for electrochemical biosensors.

InChI:InChI=1/C6H7BO3/c8-6-3-1-2-5(4-6)7(9)10/h1-4,8-10H

Upstream product

• 30418-59-8 3-Aminophenylboronic acid 
• 13331-27-6 m-nitrobenzene boronic acid 
• 121-43-7 Trimethyl borate 
• 591-20-8 3-Bromophenol 
• 108-43-0 3-monochlorophenol 
• 53087-13-1 3-(benzyloxy)phenyl bromide 
• 5419-55-6 Triisopropyl borate 
• 36971-28-5 3-Bromo-(trimethylsilyloxy)benzene 
• 156682-54-1 3-(benzyloxy)phenylboronic acid 

Downstream Products

• 204572-34-9 Acetic acid (2R,3R,4S,5S,6R)-3,5-diacetoxy-2-acetoxymethyl-6-(3'-hydroxy-5-{6-[3'-hydroxy-6-((2R,3S,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-biphenyl-3-yl]-hexyl}-biphenyl-2-yloxy)-tetrahydro-pyran-4-yl ester 
• 154848-43-8 3'-hydroxybiphenyl-3-carbonitrile 
• 681161-44-4 3′-hydroxy-(1,1′-biphenyl)-3-carboxamide 
• 176212-54-7 3'-hydoxymethylbiphenyl-3-ol 
• 858946-44-8 6-(3-hydroxyphenyl)-3,4-dihydronaphthalen-1(2H)-one 
• 911818-22-9 3-(3-hydroxy-phenoxy)-1-(3-isopropyl-phenyl)-1H-indole-2-carboxylic acid ethyl ester 
• 911817-00-0 1-(4-tert-butyl-phenyl)-3-(3-hydroxy-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 
• 862791-44-4 (1R,3R,4R)-1,4-bis(tert-butyldimethylsilyloxy)-5-(3-hydroxyphenyl)cyclohex-5-ene-1,3-carbolactone 
• 503468-79-9 8-(3-hydroxy-phenyl)-2-morpholin-4-yl-chromen-4-one 
• 868394-56-3 (3'-hydroxy-biphenyl-4-yl)-acetic acid 

Relevant articles and documents

Preparation method of hydroxyphenylboronic acid

The invention discloses a preparation method of hydroxyphenylboronic acid, which belongs to the technical field of boric acid synthesis in medical intermediates. The method comprises the following steps: starting from bromophenol, carrying out BOC, trimethylsilyl or benzyl protection, forming a Grignard reagent, reacting with borate, or carrying out one-pot reaction with borate and n-butyllithium,and hydrolyzing to obtain hydroxyphenylboronic acid. According to the invention, cheap and easily available protecting groups are adopted, so that the protecting groups are easy to remove during boronation reaction hydrolysis, industrial amplification is easy to realize, batch production is carried out on the scale of dozens of kilograms, and the process stability is good.

Palladium-catalyzed borylation of aryl and heteroaryl halides utilizing tetrakis(dimethylamino)diboron: One step greener

The palladium-catalyzed borylation of aryl and heteroaryl halides with a novel borylating agent, tetrakis(dimethylamino)diboron [(Me2N) 2B-B(NMe2)2], is reported. The method is complementary to the previously reported method utilizing bis-boronic acid (BBA) in that certain substrates perform better under one set of optimized reaction conditions than the other. Because tetrakis(dimethylamino)diboron is the synthetic precursor to both BBA and bis(pinacolato)diboron (B 2Pin2), the new method represents a more atom-economical and efficient approach to current borylation methods.

Hydroxyphenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain

Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, triazolyl and thiazolyl; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.