874809-42-4

Basic information

• Product Name: Oxirane, [[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]methyl]-, (2S)-
• CAS NO: 874809-42-4
• Molecular Formula: C15H20O3
• Molecular Weight: 248.322
• Mol File: 874809-42-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Oxirane, [[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]methyl]-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxirane, [[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]methyl]-, (2S)-(874809-42-4)
• EPA Substance Registry System: Oxirane, [[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]methyl]-, (2S)-(874809-42-4)

Safety Data

• Hazardous Substances Data: 874809-42-4(Hazardous Substances Data)

Upstream product

• 51594-55-9 (R)-(-)-epichlorohydrin 
• 63659-16-5 4-[2-(cyclopropylmethoxy)-ethyl]-phenol 
• 104857-48-9 1-[4-(2-hydroxyethyl)phenoxy]-2,3-epoxypropane 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 297741-05-0 (S)-1-[4-(2-hydroxyethyl)phenoxy]-2,3-epoxypropane 
• 7051-34-5 cyclopropylcarbinyl bromide 
• 63659-17-6 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene 

Downstream Products

• 93221-48-8 (-)-Betaxolol 

Relevant articles and documents

Concise synthesis of β-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution

Enantiopure (S)-metoprolol and (S)-betaxolol were prepared in an extremely simple and practical way using Jacobsen's hydrolytic kinetic resolution of terminal epoxides in isopropanol.

A convenient synthesis of the enantiomerically pure β-blocker (S)-betaxolol using hydrolytic kinetic resolution

Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen's catalyst. High enantiomeric purity (99% ee) has been achieved and the method is amenable to industrial scale-up.