88054-22-2Relevant articles and documents
Process for synthesizing 2 - methyl -5 nitroimidazole
-
Paragraph 0012-0017, (2021/10/05)
The invention discloses a synthesis process of 2 - methyl -5 nitroimidazole, which comprises the following steps: (1) a synthesis reaction. (2) In neutralization, centrifugation. (3) A dry package. The step (2) further comprises a sodium nitrite recovery process. The waste water is added into a multi-effect evaporation crystallizer for concentration mother liquor, sodium nitrate is crystallized out, sodium nitrate crystals are separated through a horizontal spiral centrifugal machine, and then the sodium nitrate finished product is obtained through an airflow dryer. The process is more suitable for large-scale production, the consumption of main materials is greatly reduced, concentrated sulfuric acid is not added, the production cost is lower, and the sodium nitrate - hydrochloric acid mixed system used in the invention is more favorable for removing excess nitric acid and hydrochloric acid in the reaction liquid. The product yield reaches 97.0% or more, and the product content reaches 99.8% or more.
Continuous synthesis method for 2-methyl-5-nitroimidazole
-
Paragraph 0017; 0042; 0047-0050; 0055-0058; 0063-0065, (2020/07/15)
The invention provides a continuous synthesis method for 2-methyl-5-nitroimidazole. The 2-methyl-5-nitroimidazole is synthesized in a micro-channel reactor. The synthesis method provided by the invention can realize continuous synthesis, is safe and stable in production process, extremely short in reaction time and high in yield, and can reduce the usage amount of concentrated sulfuric acid and lower cost.
Tritiated metronidazole and preparation method thereof
-
Paragraph 0037; 0038, (2017/08/28)
The invention belongs to the field of radioactive isotope labeling preparation, and particularly relates to tritiated metronidazole and a preparation method thereof. The preparation method includes: using 2-methyl-5-nitroimidazole as a raw material to react with N-iodosuccinimide to obtain 4-iodine-2-methyl-5nitroimidazole; under catalysis of palladium carbon, enabling 4-iodine-2-methyl-5nitroimidazole and tritium gas to be in tritium-halogen exchange to generate 4-3H-2-methyl-5-nitroimidazole; enabling 4-3H-2-methyl-5-nitroimidazole to react with ethylene oxide to obtain 4-3H-metronidazole. A synthetic product is purified through a prepared liquid phase to obtain4-3H-metronidazole with high specific activity (22.08Ci/g), high radiochemical purity (greater than or equal to 98%) and high chemical purity (greater than or equal to 98%). The tritiated metronidazole can be used as a radioactive tracer in studying absorption, distribution, metabolism and residue elimination of metronidazole in animal bodies.