881683-80-3 Usage
Description
(S)-ethyl 2-(tert-butoxycarbonylamino)-5-oxonon-8-enoate is a chemical compound with the molecular formula C13H21NO5. It is an ester derivative of (S)-2-aminoglutaric acid and is recognized for its versatile reactivity and biological activity. (S)-ethyl 2-(tert-butoxycarbonylamino)-5-oxonon-8-enoate serves as a crucial building block in the synthesis of various pharmaceuticals and biologically active compounds.
Uses
Used in Pharmaceutical Synthesis:
(S)-ethyl 2-(tert-butoxycarbonylamino)-5-oxonon-8-enoate is used as a key intermediate for the synthesis of pharmaceuticals. Its ability to selectively inhibit the enzyme gamma-secretase, which is involved in the production of amyloid-beta peptides associated with Alzheimer's disease, makes it a valuable compound in the development of potential treatments for this condition.
Used in the Synthesis of Biologically Active Compounds:
(S)-ethyl 2-(tert-butoxycarbonylamino)-5-oxonon-8-enoate is also used as a building block for the synthesis of biologically active compounds, contributing to the development of new drugs and therapies.
Used in the Synthesis of Peptidomimetics:
(S)-ethyl 2-(tert-butoxycarbonylamino)-5-oxonon-8-enoate is used as a starting material for the synthesis of peptidomimetics, which are synthetic compounds that mimic the structure and function of peptides. These peptidomimetics have potential applications in various fields, including drug design and the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 881683-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,1,6,8 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 881683-80:
(8*8)+(7*8)+(6*1)+(5*6)+(4*8)+(3*3)+(2*8)+(1*0)=213
213 % 10 = 3
So 881683-80-3 is a valid CAS Registry Number.
881683-80-3Relevant articles and documents
CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF
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Paragraph 00355, (2017/09/27)
The present technology relates to compounds, kits, compositions, and methods useful for the treatment of fibrotic disease. In some aspects, the present technology provides for treatment of various diseases or disorders associated or mediated, at least in part, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is generally applicable to compounds which inhibit myofibroblast differentiation.
Design and synthesis of novel fluoro amino acids: synthons for potent macrocyclic HCV NS3 protease inhibitors
Nair, Latha G.,Bogen, Stephane,Bennett, Frank,Chen, Kevin,Vibulbhan, Bancha,Huang, Yuhua,Yang, Weing,Doll, Ronald J.,Shih,Njoroge, F. George
supporting information; experimental part, p. 3057 - 3061 (2010/08/05)
The Hepatitis C Virus (HCV) is a major health hazard and its infection is a leading cause of chronic liver disease world wide. In our efforts toward the discovery of a back up to our first clinical candidate, Boceprevir (SCH 503034), we approached the depeptidization of the molecule through macrocyclization. Herein we report the design and synthesis of fluoro amino acids with desired stereochemistry required for the synthesis of macrocyclic inhibitors with fluorine at various positions of the aliphatic chain. Biological activities of representative examples are also reported.
